ArticleNature2018
Inositol phosphates are assembly co-factors for HIV-1.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 191 papers.
0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
191 citing papers in PubMed, 273 citations in OpenAlex.
- The Central Pore of HIV-1 Capsomers Promotes Sustained Stability of the Viral Capsid.Journal of molecular biology · 2026Article
- Mechanism of HIV-1 capsid rupture and uncoating by reverse transcription.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026Review
- Structural basis of lenacapavir-induced HIV-1 capsid defects during virion maturation.Nature communications · 2026Article
- Host soluble inositol phosphate signaling promotes coronavirus replication.bioRxiv : the preprint server for biology · 2026Article
- MxB N-Terminus Adopts a Stable α-Helix to Engage the HIV-1 Capsid Trimer Interface.bioRxiv : the preprint server for biology · 2026Article
- IPMK at the crossroads of cellular signaling in health and disease.FEBS letters · 2026Review
- Phosphoinositides and inositol phosphates as molecular glues.FEBS letters · 2026Review
- Retroviruses use different IPNature communications · 2026Article
- Article
- Capsid and integrase play essential apposing roles in viral ribonucleoprotein assembly during HIV-1 core morphogenesis.iScience · 2026Article
- Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.ACS chemical biology · 2026Article
- Article
- Mechanism of HIV-1 Capsid Rupture and Uncoating by Reverse Transcription.bioRxiv : the preprint server for biology · 2026Article
- MX2 Mediates Collapse of the HIV-1 Capsid.bioRxiv : the preprint server for biology · 2026Article
- Atomistic characterization of the maturation mechanisms in the HIV-1 capsid domain.Nature communications · 2026Article
- Damaging the conical morphology of HIV-1 capsid by targeting the FG-binding pocket and disfavoring pentameric subunits needed for core closure.bioRxiv : the preprint server for biology · 2026Article
- Mechanistic insights into lenacapavir-induced off-pathway HIV-1 capsid assembly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Recurrent and novel evolutionary pathways drive in vitro HIV-1 lenacapavir resistance with diverse phenotypic consequences.Nature communications · 2026Article
- Lenacapavir prevents production of infectious HIV-1 by abrogating immature virus assembly.bioRxiv : the preprint server for biology · 2026Article
131 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 5 institutions in 2 countries.
Robert A DickDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. rad82@cornell.edu.
Kaneil K ZadroznyDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Chaoyi XuDepartment of Chemistry and Biochemistry, University of Delaware, Newport, DE, USA.
Florian K M SchurStructural and Computational Biology Unit, EMBL, Heidelberg, Germany.
Terri D LyddonDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA.
Clifton L RicanaDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA.
Jonathan M WagnerDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Juan R PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newport, DE, USA.
Barbie K Ganser-PornillosDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA.
Marc C JohnsonDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, USA.
Owen PornillosDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. opornillos@virginia.edu.
Volker M VogtDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
University of Virginia · USUniversity of Missouri · USCornell University · USUniversity of Delaware · USInstitute of Science and Technology Austria · AT
Funding
X-Ray Core P50GM082251 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO · 2007 to 2018
$48.1MThe Center for HIV RNA Studies (CRNA)P50GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAYIE, KWAKU · 2012 to 2016
$21.7MThe Center for HIV RNA Studies (CRNA)U54GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TELESNITSKY, ALICE · 2017 to 2018
$10.2MPilot Research Subproject ProgramP30GM110758 · NIGMS · UNIVERSITY OF DELAWARE · PI BEEBE, THOMAS PAUL · 2014 to 2018
$5.8MBreakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0MMolecular mechanisms of the CA-SP1 switch in HIV assembly and maturationR01AI129678 · NIAID · UNIVERSITY OF VIRGINIA · PI GANSER-PORNILLOS, BARBIE K., PORNILLOS, OWEN · 2017 to 2021
$2.3MStructure and Assembly of RetrovirusesR01GM107013 · NIGMS · CORNELL UNIVERSITY · PI VOGT, VOLKER M. · 2013 to 2018
$1.5MElucidation of HIV Env acquisition strategiesR01GM110776 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI JOHNSON, MARC C · 2013 to 2016
$1.2MControl of Retrovirus Assembly by Membrane Lipid Thermodynamic Activity.R01GM105684 · NIGMS · CORNELL UNIVERSITY · PI FEIGENSON, GERALD WILLIAM · 2013 to 2016
$1.2MStructure and Assembly of RetrovirusesR01AI150454 · NIAID · CORNELL UNIVERSITY · PI VOGT, VOLKER M. · 2019 to 2020
$719kStructural and Functional Integration of TRIM5alpha Domains for HIV Capsid BindingF32GM115007 · NIGMS · UNIVERSITY OF VIRGINIA · PI WAGNER, JONATHAN MARK · 2015 to 2017
$173kNIAID NIH HHS R01 AI129678NIAID NIH HHS R01 AI150454NIGMS NIH HHS F32 GM115007NIGMS NIH HHS P30 GM110758NIGMS NIH HHS P50 GM082251NIGMS NIH HHS P50 GM103297NIGMS NIH HHS R01 GM105684NIGMS NIH HHS R01 GM107013NIGMS NIH HHS R01 GM110776NIGMS NIH HHS R01 GM116961NIGMS NIH HHS U54 GM103297
Abstract
A short, 14-amino-acid segment called SP1, located in the Gag structural protein
Indexed as
Virus AssemblyArginineCapsidCrystallography, X-Raygag Gene Products, Human Immunodeficiency VirusHIV-1Inositol PhosphatesIn Vitro TechniquesLysineModels, MolecularMolecular Dynamics SimulationVirionArgininegag Gene Products, Human Immunodeficiency VirusInositol PhosphatesLysine
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.