ArticleNature2018
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.
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193citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
193 citing papers in PubMed, 305 citations in OpenAlex.
- Dynamic regulation of H3K9 modifications in cancer: pathogenesis and targeted therapies.Biomarker research · 2026Review
- Targeting the Chromatin-Modifying Enzyme, KDM5C, Enhances AKT Inhibition Response in ER+ Breast Cancer.Molecular cancer therapeutics · 2026Article
- Reframing cancer therapy through tumor plasticity.Nature cancer · 2026Review
- KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches.Acta crystallographica. Section D, Structural biology · 2026Article
- Targeting MYC-Driven Cancers: From Oncogenic Addiction to Therapeutic Vulnerability.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026Review
- Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer.Signal transduction and targeted therapy · 2026Review
- Tumor cells escape from therapy-induced senescence: from molecular mechanisms to targeted intervention.Biology direct · 2026Review
- The roles of the acetyltransferase domains of the chromatin regulators KAT6A and KAT6B in vivo.Development (Cambridge, England) · 2026Article
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- JAK-STAT signaling pathway in cancer: from molecular mechanisms to clinical intervention.Molecular cancer · 2026Review
- Hierarchical small molecule inhibition of MYST acetyltransferases.Nature communications · 2026Article
- Exploiting cellular senescence in hematologic malignancies.Translational oncology · 2026Review
- KAT6A is essential for developmental control gene expression in neural stem and progenitor cells.PLoS genetics · 2026Article
- A Perturb-seq map of a differentiation hub reveals synergistic vulnerabilities in KMT2A-rearranged acute myeloid leukemia.Leukemia · 2026Article
- Acetyl-carnitine improves hyperactivity and learning deficits inLife science alliance · 2026Article
- Epigenetic deciphering of ovarian aging: multilayer interactive mechanisms and targeted reversal strategies.Epigenetics & chromatin · 2026Review
- Lysine Acetyltransferase 6A Drives M1 Macrophage Polarization Through Metabolic Reprogramming in Sepsis-Induced Acute Lung Injury.Biomolecules · 2026Article
- Beyond CDK4/6 Inhibition: Current Strategies in Hormone Receptor-Positive Metastatic Breast Cancer.Current treatment options in oncology · 2026Review
- Hybrid extracellular vesicles drive irreversible mitochondria damage and TCA metabolite deficiency-related chondrocyte senescence.Innovation (Cambridge (Mass.)) · 2026Article
- Compressive stress-driven Piezo1 activation and Rho-ROCK mechanotransduction promote tumor progression via epigenetic mechanical memory.Science advances · 2026Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
52 authors at 8 institutions in 2 countries.
Jonathan B BaellMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Jonathan.Baell@monash.edu.
David J LeaverMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Stefan J HermansACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Gemma L KellyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Margs S BrennanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Natalie L DownerThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Nghi NguyenMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Johannes WichmannThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Helen M McRaeThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Yuqing YangThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Ben ClearyMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
H Rachel LagiakosMedicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Stephen MieruszynskiThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Guido PaciniThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Hannah K VanyaiThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Maria I BergamascoThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Rose E MayThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Bethany K DaveyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Kimberly J MorganThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Andrew J SealeyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Beinan WangThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Natasha ZamudioThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Stephen WilcoxThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Alexandra L GarnhamThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Bilal N SheikhThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Brandon J AubreyThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Karen DoggettThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Matthew C ChungACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Melanie de SilvaThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
John BentleyCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Pat PillingCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Meghan HattarkiCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Olan DolezalCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Matthew L DennisCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Hendrik FalkThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Bin RenCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Susan A CharmanCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Karen L WhiteCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Jai RautelaThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Andrea NewboldThe Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Edwin D HawkinsThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Ricky W JohnstoneThe Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Nicholas D HuntingtonThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Thomas S PeatCommonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia.
Joan K HeathThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Andreas StrasserThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Michael W ParkerACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.
Gordon K SmythThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Ian P StreetThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Brendon J MonahanThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. avoss@wehi.edu.au.
Tim ThomasThe Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. tthomas@wehi.edu.au.
Walter and Eliza Hall Institute of Medical Research · AUUniversity of Melbourne · AUCommonwealth Scientific and Industrial Research Organisation · AUMonash University · AUSt Vincents Institute of Medical Research · AUPaediatric Integrated Cancer Service · AUPeter MacCallum Cancer Centre · AUTsinghua University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylation of histones by lysine acetyltransferases (KATs) is essential for chromatin organization and function
Indexed as
AcetylationAnimalsBenzenesulfonatesBiphenyl CompoundsCell ProliferationCells, CulturedCellular SenescenceDrug DevelopmentFibroblastsGene Expression Regulation, NeoplasticHistone AcetyltransferasesHistonesHydrazinesLymphomaLysineMale(1,1'-Biphenyl)-3-carboxylic acid, 4-fluoro-5-methyl-, 2-(phenylsulfonyl)hydrazide2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazideBenzenesulfonatesBiphenyl CompoundsHistone AcetyltransferasesHistonesHydrazinesKAT6A protein, mouseLysineSulfonamides
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What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.