ArticleNature2018
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
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Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 766 papers.
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766citing papers in PubMed
98.2field-weighted citation impact, top 1% of its field
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Who cites it
766 citing papers in PubMed, 1,235 citations in OpenAlex.
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Authors and funding
29 authors at 7 institutions in 2 countries.
Daniel T MontoroCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Adam L HaberKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Moshe BitonKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Vladimir VinarskyCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Brian LinCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Susan E BirketDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Feng YuanDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Sijia ChenDepartment of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands.
Hui Min LeungDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Jorge VilloriaCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Noga RogelKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Grace BurginKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alexander M TsankovKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Avinash WaghrayCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Michal SlyperKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Julia WaldmanKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Lan NguyenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Danielle DionneKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Orit Rozenblatt-RosenKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Purushothama Rao TataDepartment of Cell Biology, Duke University, Durham, NC, USA.
Hongmei MouDepartment of Pediatrics, Massachusetts General Hospital, Boston, MA, USA.
Manjunatha ShivarajuCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA.
Hermann BihlerCFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Martin MenseCFFT Lab, Cystic Fibrosis Foundation, Lexington, MA, USA.
Guillermo J TearneyDepartment of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Steven M RoweDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
John F EngelhardtDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.
Jayaraj RajagopalCenter for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA. jrajagopal@mgh.harvard.edu.
Broad Institute · USHarvard Stem Cell Institute · USCystic Fibrosis Foundation · USMassachusetts General Hospital · USUniversity of Iowa · USDuke University · USUniversity of Amsterdam · NL
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI MCCRAY, PAUL B · 1993 to 2019
$36.5MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5MUAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0MTranslational Program in CFTR-Related Airway DiseasesR35HL135816 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROWE, STEVEN MARK · 2017 to 2022
$6.3MNational Ferret Resource and Research Center on Lung DiseaseR24HL123482 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2014 to 2018
$3.8MMODELS OF SUBMUCOSAL GLAND DEVELOPMENT AND FUNCTIONR01DK047967 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ENGELHARDT, JOHN F · 1993 to 2020
$3.8MTAAR1 agonists for nicotine addictionR01DA047967 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LI, JUN-XU · 2019 to 2023
$2.0MTo define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationR00HL127181 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2017 to 2019
$738kThe Mechanisms Underlying Abnormal Mucus and its Clearance in the Cystic Fibrosis RatK08HL131867 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2017 to 2021
$637kTo define the role of SOX9 and Sox9+ cells in alveolar homeostasis and regenerationK99HL127181 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI TATA, PURUSHOTHAMA RAO · 2015 to 2016
$273kNHLBI NIH HHS F31 HL136128NHLBI NIH HHS K08 HL131867NHLBI NIH HHS K99 HL127181NHLBI NIH HHS P01 HL051670NHLBI NIH HHS R00 HL127181NHLBI NIH HHS R24 HL123482NHLBI NIH HHS R35 HL135816NIDA NIH HHS R01 DA047967NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK054759NIDDK NIH HHS P30 DK072482NIDDK NIH HHS R01 DK047967NIEHS NIH HHS P30 ES005605
Abstract
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing. We identify a rare cell type, the Foxi1
Indexed as
AnimalsAsthmaCell DifferentiationCell LineageCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorEpithelial CellsFemaleForkhead Transcription FactorsGene Expression ProfilingGene Expression RegulationGoblet CellsHumansLungMaleMiceCFTR protein, humanCftr protein, mouseCystic Fibrosis Transmembrane Conductance RegulatorForkhead Transcription FactorsFoxi1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.