ArticleScientific reports2018
LED based real-time survival bioassays for nematode research.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Geroprotective drug discovery with an AI-enabled assay for heat resistance.bioRxiv : the preprint server for biology · 2026Article
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- Selection of indigenous bacterial strains having the ability to promote plant growth and control root-knot nematode Meloidogyne spp. on Malabar spinach in Vietnam.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- MitigatingBiofilm · 2025Article
- Description ofJournal of nematology · 2024Article
- Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities.Materials (Basel, Switzerland) · 2023Article
- Characterizing Three Azides for Their Potential Use asmicroPublication biology · 2023Article
- Grafted Chitosan-Hyaluronic Acid (CS-g-poly (MA-co-AN) HA) Complex Inhibits Fluconazole-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Appraisal of Cinnamaldehyde Analogs as Dual-Acting Antibiofilm and Anthelmintic Agents.Frontiers in microbiology · 2022Article
- Enface vitreous OCT 'worm holes': A novel finding in a patient with diffuse unilateral subacute neuroretinitis (DUSN).American journal of ophthalmology case reports · 2021Article
- Hydropic anthelmintics against parasitic nematodes.PLoS pathogens · 2020Article
- Antibiofilm and Antivirulence Efficacies of Flavonoids and Curcumin AgainstFrontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nematode bioassays are extensively conducted worldwide, either for screening anthelmintic drugs or for assessing the toxicity of drug candidates. Recently, the US Environmental Protection Agency mandated the use of invertebrate models including nematodes especially Caenorhabditis elegans, for toxicity testing as an alternative to rodent models. The significance of nematode bioassays in the biological sciences is escalating, but no standardized protocol is available to assess nematode mortality in a liquid medium. Manual counting under white light is the only approach currently practiced, which exhibit large variabilities and false positive results. Here, we describe an innovative counting strategy that employs light-emitting diode (LED) technology. We found that the nematodes stopped moving under white light (360-760 nm) when administered with sub-lethal dosage (LC
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