ArticleTranslational psychiatry2018
Male increase in brain gene expression variability is linked to genetic risk for schizophrenia.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- The association between plasma betaine level and brain structural changes in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Greater variability in rhesus macaque (Proceedings. Biological sciences · 2022Article
- Males and females with first episode psychosis present distinct profiles of social cognition and metacognition.European archives of psychiatry and clinical neuroscience · 2022Article
- A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function.Scientific reports · 2022Article
- Sex-specific up-regulation of lncRNAs in peripheral blood of patients with schizophrenia.Scientific reports · 2019Article
- The widespread increase in inter-individual variability of gene expression in the human brain with age.Aging · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia shows substantial sex differences in age of onset, course, and treatment response, but the biological basis of these effects is incompletely understood. Here we show that during human development, males show a regionally specific decrease in brain expression similarity compared to females. The genes modulating this effect were significantly co-expressed with schizophrenia risk genes during prefrontal cortex brain development in the fetal period as well as during early adolescence. This suggests a genetic contribution to a mechanism through which developmental abnormalities manifest with psychosis during adolescence. It further supports sex differences in brain expression variability as a factor underlying the well-established sex differences in schizophrenia.
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