ArticleNature communications2018
Linked dimensions of psychopathology and connectivity in functional brain networks.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 262 papers, 4 of them syntheses that pooled it.
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262citing papers in PubMed, 4 pooled it
26.2field-weighted citation impact, top 1% of its field
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Who cites it
262 citing papers in PubMed, 4 syntheses or guidelines pooled it, 471 citations in OpenAlex.
- The hierarchical taxonomy of psychopathology and the search for neurobiological substrates of mental illness: A systematic review and roadmap for future research.Journal of psychopathology and clinical science · 2024Pooled it
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis.Molecular psychiatry · 2023Pooled it
- Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Individualized fMRI connectivity defines signatures of antidepressant and placebo responses in major depression.Molecular psychiatry · 2023Trial
- Executive functions as a transdiagnostic endophenotype in developmental psychopathology.Molecular psychiatry · 2026Review
- The Relationship between Air Pollution Exposure, Genetic Liability for Schizophrenia, and Brain Outcomes in the ABCD Study.Schizophrenia bulletin · 2026Article
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- NeuroFusion: A Unified Framework for Generalized Visual Stimulus Decoding from fMRI Across Datasets and Subjects.Neuroinformatics · 2026Article
- The topology of adolescent mental health.medRxiv : the preprint server for health sciences · 2026Article
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Multivariate relationships between social cognitive performance and functional connectivity during task and rest across schizophrenia spectrum disorders and healthy controls.Molecular psychiatry · 2026Article
- Developmental Timing and Network Directionality in the Triple-Network Model of Anorexia Nervosa.Biological psychiatry global open science · 2026Article
- Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.Nature communications · 2026Article
- Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning.bioRxiv : the preprint server for biology · 2026Article
- Multi-omic analysis of deep learning-derived phenotypes links ophthalmic imaging to cardiovascular and neurological traits.Nature cardiovascular research · 2026Article
- Symptom-specific links between internalizing problems and functional connectivity in adolescents: a network analysis.European child & adolescent psychiatry · 2026Article
- Alterations in resting-state functional connectivity relate to psychopathology trajectories during emerging adolescence.JCPP advances · 2026Article
202 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 2 institutions in 2 countries.
Cedric Huchuan XiaDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zongming MaDepartment of Statistics, The Wharton School, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Rastko CiricDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Shi GuDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Richard F BetzelDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Antonia N KaczkurkinDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Monica E CalkinsDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Philip A CookDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Angel García de la GarzaDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Simon N VandekarDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zaixu CuiDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Tyler M MooreDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
David R RoalfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kosha RuparelDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Daniel H WolfDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Christos DavatzikosDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ruben C GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Raquel E GurDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Russell T ShinoharaDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Danielle S BassettDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-6183-4493
Theodore D SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. sattertt@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-7072-9399
University of Pennsylvania · USUniversity of Electronic Science and Technology of China · CN
Funding
Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089983 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2009 to 2011
$14.3M2/2 Neurodevelopmental Genomics: Trajectories of Complex PhenotypesRC2MH089924 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HAKONARSON, HAKON · 2009 to 2011
$10.7MNMDA Receptor Hypofunction in the Amygdala of Schizophrenia PatientsP50MH096891 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2012 to 2016
$10.6MLongitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9MThe Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 2016 to 2020
$6.3MPersonalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0MInter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9MLinguistic and NonLinguistic Functions of Frontal CortexR01DC009209 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI THOMPSONSCHILL, SHARON L · 2008 to 2018
$5.2MLongitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6MVirtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3MStatistical methods for large and complex databases of ultra-high-dimensionalR01NS085211 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SHINOHARA, RUSSELL TAKESHI · 2013 to 2017
$1.8MQuantitative Behavioral and Imaging Phenotypes of Amotivation in SchizophreniaR01MH101111 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI WOLF, DANIEL H · 2013 to 2016
$1.6MNIBIB NIH HHS R01 EB022573NICHD NIH HHS R01 HD086888NICHD NIH HHS U54 HD086984NIDCD NIH HHS R01 DC009209NIMH NIH HHS K01 MH102609NIMH NIH HHS K08 MH079364NIMH NIH HHS P50 MH096891NIMH NIH HHS R01 MH101111NIMH NIH HHS R01 MH107235NIMH NIH HHS R01 MH107703NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R21 MH106799NIMH NIH HHS RC2 MH089924NIMH NIH HHS RC2 MH089983NINDS NIH HHS R01 NS085211NINDS NIH HHS R01 NS099348U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB022573U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K01MH102609U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K08MH079364U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH089924U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH089983U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P50MH096891U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH101111U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH107235U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH107703U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH112847U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21MH106799U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS085211
Abstract
Neurobiological abnormalities associated with psychiatric disorders do not map well to existing diagnostic categories. High co-morbidity suggests dimensional circuit-level abnormalities that cross diagnoses. Here we seek to identify brain-based dimensions of psychopathology using sparse canonical correlation analysis in a sample of 663 youths. This analysis reveals correlated patterns of functional connectivity and psychiatric symptoms. We find that four dimensions of psychopathology - mood, psychosis, fear, and externalizing behavior - are associated (r = 0.68-0.71) with distinct patterns of connectivity. Loss of network segregation between the default mode network and executive networks emerges as a common feature across all dimensions. Connectivity linked to mood and psychosis becomes more prominent with development, and sex differences are present for connectivity related to mood and fear. Critically, findings largely replicate in an independent dataset (n = 336). These results delineate connectivity-guided dimensions of psychopathology that cross clinical diagnostic categories, which could serve as a foundation for developing network-based biomarkers in psychiatry.
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PsychopathologyAdolescentAdultBrainChildCohort StudiesFemaleHumansMaleMultivariate AnalysisNerve NetReproducibility of ResultsSex CharacteristicsYoung Adult
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