ArticleThe ISME journal2018
Culture- and metagenomics-enabled analyses of the Methanosphaera genus reveals their monophyletic origin and differentiation according to genome size.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Comparative metataxonomic analysis of total, viable, and active rumen microbial communities under methane-mitigated conditions.Environmental microbiome · 2026Article
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- Exploring the link between ruminal methane production and physiological changes in Japanese Black cattle during fattening.Scientific reports · 2026Article
- A fixed methane filter maximizes freshwater emissions under warming.Nature climate change · 2026Article
- Refining microbial biomarker identification in rumen microbiome studies: a viability PCR-based approach.Applied and environmental microbiology · 2025Article
- Complete genome sequence ofMicrobiology resource announcements · 2024Article
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- Holistic View and Novel Perspective on Ruminal and Extra-Gastrointestinal Methanogens in Cattle.Microorganisms · 2023Review
- Novel complete methanogenic pathways in longitudinal genomic study of monogastric age-associated archaea.Animal microbiome · 2023Article
- Isolation and characterisation of novel Methanocorpusculum species indicates the genus is ancestrally host-associated.BMC biology · 2023Article
- Evolving understanding of rumen methanogen ecophysiology.Frontiers in microbiology · 2023Review
- Diversity and taxonomic revision of methanogens and other archaea in the intestinal tract of terrestrial arthropods.Frontiers in microbiology · 2023Article
- The evolving role of methanogenic archaea in mammalian microbiomes.Frontiers in microbiology · 2023Review
- Isolation of a Novel Thermophilic Methanogen and the Evolutionary History of the ClassBiology · 2022Article
- Rumen and fecal microbiota profiles associated with immunity of young and adult goats.Frontiers in immunology · 2022Article
- Simulated seasonal diets alter yak rumen microbiota structure and metabolic function.Frontiers in microbiology · 2022Article
- The Impact of Pre-Slaughter Fasting on the Ruminal Microbial Population of Commercial Angus Steers.Microorganisms · 2021Article
- Clinical medicine journals lag behind science journals with regards to "microbiota sequence" data availability.Clinical and translational medicine · 2021Article
- State of the Art in the Culture of the Human Microbiota: New Interests and Strategies.Clinical microbiology reviews · 2020Review
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Authors and funding
12 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The genus Methanosphaera is a well-recognized but poorly characterized member of the mammalian gut microbiome, and distinctive from Methanobrevibacter smithii for its ability to induce a pro-inflammatory response in humans. Here we have used a combination of culture- and metagenomics-based approaches to expand the representation and information for the genus, which has supported the examination of their phylogeny and physiological capacity. Novel isolates of the genus Methanosphaera were recovered from bovine rumen digesta and human stool, with the bovine isolate remarkable for its large genome size relative to other Methanosphaera isolates from monogastric hosts. To substantiate this observation, we then recovered seven high-quality Methanosphaera-affiliated population genomes from ruminant and human gut metagenomic datasets. Our analyses confirm a monophyletic origin of Methanosphaera spp. and that the colonization of monogastric and ruminant hosts favors representatives of the genus with different genome sizes, reflecting differences in the genome content needed to persist in these different habitats.
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