Evidence map›Paper›PMID 30068928›Full record

ArticleEye (London, England)2018

Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen.

Maximilian Pfau, Moritz Lindner, Martin Gliem, Julia S Steinberg, Sarah Thiele, Robert P Finger, Monika Fleckenstein, Frank G Holz, Steffen Schmitz-Valckenberg

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 59 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Maximilian PfauDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Moritz LindnerDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.ORCID http://orcid.org/0000-0002-4416-3421
Martin GliemDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Julia S SteinbergDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Sarah ThieleDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Robert P FingerDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Monika FleckensteinDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Frank G HolzDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany.
Steffen Schmitz-ValckenbergDepartment of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, Bonn, Germany. steffen.schmitz-valckenberg@ukbonn.de.
University of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data.

methodsForty-four eyes (24 eyes of 24 patients with drusen, age 69.4 ± 12.6 years; 20 normal eyes of 16 subjects, 61.7 ± 12.4 years) underwent duplicate mesopic, dark-adapted cyan and dark-adapted red FCP within 14° of the central retina (total of 12 936 threshold tests) using the Scotopic Macular Integrity Assessment (S-MAIA, CenterVue, Padova, Italy) device. FCP data were registered to SD-OCT data to obtain outer nuclear layer, inner and outer photoreceptor segment, and retinal pigment epithelium drusen complex (RPEDC) thickness data spatially corresponding to the stimulus location and area (0.43°). Structure-function correlations were assessed using mixed-effects models.

resultsMean deviation values for eyes with cuticular, soft, and reticular drusen were similar for mesopic (-2.1, -3.4, and -3.6 dB) and dark-adapted red (-1.4, -2.6, and -3.3 dB) FCP. For the dark-adapted cyan FCP (0.1, -1.9, and -5.0 dB) and for the cyan-red sensitivity difference (+1.0, +0.5, and -2.4 dB), the mean deviation values differed significantly in dependence of the predominant drusen type (one-way ANOVA; p < 0.05). RPEDC thickness was associated with reduction of mesopic sensitivity (-0.34 dB/10 µm RPEDC thickening; p < 0.001), dark-adapted cyan sensitivity (-0.11 dB/10 µm RPEDC thickening; p = 0.003), and dark-adapted red sensitivity (-0.26 dB/10 µm RPEDC thickening; p < 0.001).

conclusionsIn contrast to mesopic FCP, dark-adapted two-color FCP allowed for meaningful differential testing of rod and cone function in patients with drusen indicating predominant cone dysfunction in eyes with cuticular drusen and predominant rod dysfunction in eyes with reticular drusen. RPEDC thickness was the strongest predictor of the evaluated SD-OCT biomarkers for point-wise sensitivity.

Indexed as

AgedAged, 80 and overAnalysis of VarianceDark AdaptationFemaleHumansMacular DegenerationMaleMesopic VisionMiddle AgedRetinal DrusenTomography, Optical CoherenceVisual FieldsVisual Field Tests

Identifiers

PMID30068928
PMCPMC6292882
OpenAlexW2885918621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.