ArticleNature communications2018
Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain-controlled Spinal Cord Stimulation in Patients With Spinal Cord Injury
Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation
Who cites it
76 citing papers in PubMed, 141 citations in OpenAlex.
- Training with noninvasive brain-machine interface, tactile feedback, and locomotion to enhance neurological recovery in individuals with complete paraplegia: a randomized pilot study.Scientific reports · 2022Trial
- Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis.Nature medicine · 2022Trial
- Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.Experimental neurology · 2021Trial
- Brain-spine interface: an exploration of a potential future treatment for spinal cord injury.Neurosurgical review · 2026Review
- Cross-region neural signal reconstruction to lift electrode placement constraints in SSVEP brain-computer interfaces.npj biomedical innovations · 2026Article
- Sensor Inputs and Closed-Loop Neuromodulation in Spinal Cord Injury: From Animal Models to Clinical Translation.Sensors (Basel, Switzerland) · 2026Review
- Review of Recent Advances in Implantable Brain-Computer Interfaces for the Restoration of Motor Function in Patients With Paralysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Review
- A Bidirectional Neural Interface With Direct On-Device Neuromorphic Decoding for Closed-Loop Optogenetics.bioRxiv : the preprint server for biology · 2026Article
- A general model based on Riemannian manifold for stable decoding movement trajectory from ECoG signals.iScience · 2026Article
- The Interplay Between Neuromodulation and Stem Cell Therapy for Sensory-Motor Neuroplasticity After Spinal Cord Injury: A Perspective View.Journal of clinical medicine · 2026Article
- Non-invasive closed-loop spinal stimulation restores leg stepping control in humans with paraplegia.Brain : a journal of neurology · 2026Article
- Immediate Consequences of a Spinal Cord Injury During Development: Unique Insights From Ex Vivo Models.Neural plasticity · 2026Review
- Transcutaneous stimulation of the cervical spinal cord facilitates motoneuron firing and improves hand-motor function after spinal cord injury.Journal of neurophysiology · 2025Article
- Managing surface energy dynamics for enhanced axonal growth: An overview of present and future challenges.Biophysics reviews · 2025Review
- Development and evaluation of a non-invasive brain-spine interface using transcutaneous spinal cord stimulation.Journal of neuroengineering and rehabilitation · 2025Article
- Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury.Animal models and experimental medicine · 2025Article
- Deep Brain Stimulation and Brain-Spine Interface for Functional Restoration in Spinal Cord Injury.Biomedicines · 2025Review
- Article
- Functional plasticity of glutamatergic neurons of medullary reticular nuclei after spinal cord injury in mice.Nature communications · 2024Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practical features necessary to be deployed daily during gait rehabilitation. Rats received a severe spinal cord contusion that led to leg paralysis. We engineered a proportional brain-spine interface whereby cortical ensemble activity constantly determines the amplitude of spinal cord stimulation protocols promoting leg flexion during swing. After minimal calibration time and without prior training, this neural bypass enables paralyzed rats to walk overground and adjust foot clearance in order to climb a staircase. Compared to continuous spinal cord stimulation, brain-controlled stimulation accelerates and enhances the long-term recovery of locomotion. These results demonstrate the relevance of brain-controlled neuromodulation therapies to augment recovery from motor disorders, establishing important proofs-of-concept that warrant clinical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.