ArticleGenes & development2018
The LIN28B-IMP1 post-transcriptional regulon has opposing effects on oncogenic signaling in the intestine.
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Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.American journal of physiology. Gastrointestinal and liver physiology · 2026Article
- The RNA-binding protein Imp1 promotes a Spdef transcriptional program and mucus fucosylation during necrotizing enterocolitis.bioRxiv : the preprint server for biology · 2026Article
- Marked for Success: How RNA mCellular and molecular gastroenterology and hepatology · 2026Review
- Ribosome profiling: a powerful tool in oncological research.Biomarker research · 2024Review
- Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival.JCI insight · 2023Article
- The role of LIN28B in tumor progression and metastasis in solid tumor entities.Oncology research · 2023Review
- Peptides from the croceine croaker (Pharmaceutical biology · 2022Article
- IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- The landscape of transcriptional and translational changes over 22 years of bacterial adaptation.eLife · 2022Article
- Imp interacts with Lin28 to regulate adult stem cell proliferation in the Drosophila intestine.PLoS genetics · 2022Article
- LIN28B induces a differentiation program through CDX2 in colon cancer.JCI insight · 2021Article
- PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism.Cell stem cell · 2019Article
- Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3.Genes & development · 2019Article
- IMP1 3' UTR shortening enhances metastatic burden in colorectal cancer.Carcinogenesis · 2019Article
- Posttranscriptional regulation of colonic epithelial repair by RNA binding protein IMP1/IGF2BP1.EMBO reports · 2019Article
- RNA regulons are essential in intestinal homeostasis.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 1 country.
Priya Chatterji *Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Kathryn E Hamilton *Department of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Shun LiangDepartment of Genetics, Rutgers University, New Brunswick, New Jersey 08901, USA.
Sarah F AndresDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
H R Sagara WijeratneDepartment of Genetics, Rutgers University, New Brunswick, New Jersey 08901, USA.
Rei MizunoDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Lauren A SimonDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Philip D HicksDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Shawn W FoleyDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA.
Jason R PitarresiDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
Andres J Klein-SzantoDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Amanda T MahDepartment of Medicine, Hematology Division, Stanford University, Stanford, California 94305, USA.
Laurianne Van LandeghemDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA.
Brian D GregoryDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19014, USA.
Christopher J LengnerDepartment of Biomedical Sciences, School of Veterinary Medicine, Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Blair B MadisonDepartment of Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Premal ShahDepartment of Genetics, Rutgers University, New Brunswick, New Jersey 08901, USA.
Anil K RustgiDepartment of Medicine, Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19014, USA.
University of Pennsylvania · USRutgers, The State University of New Jersey · USCalifornia Institute for Regenerative Medicine · USChildren's Hospital of Philadelphia · USFox Chase Cancer Center · USNorth Carolina State University · USStanford University · USWashington University in St. Louis · US
Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5MPREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3MThe LIN28b-Let7-IMP1 axis in colonic epithelial biologyR01DK056645 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI RUSTGI, ANIL K · 2000 to 2021
$6.8MTraining In Tumor VirologyT32CA115299 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ROBERTSON, ERLE S. · 2006 to 2021
$4.7MDynamics and evolution of translational regulationR35GM124976 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SHAH, PREMAL R · 2017 to 2021
$1.9MRole of LIN28B in the regulation of intestinal epithelial growthK01DK093885 · NIDDK · WASHINGTON UNIVERSITY · PI MADISON, BLAIR BERNARD · 2012 to 2016
$647kThe role of IMP1 mRNA binding protein in intestinal epithelial biologyK01DK100485 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI HAMILTON, KATHRYN ELIZABETH · 2014 to 2018
$631kIMP1 REGULATION OF AUTOPHAGY IN THE INTESTINAL EPITHELIUMR03DK114463 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI HAMILTON, KATHRYN ELIZABETH · 2017 to 2018
$156kInterplay of IMP1 and autophagy in intestinal barrier function and tumorigenesisF32DK107052 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ANDRES, SARAH · 2015 to 2017
$109kNCI NIH HHS T32 CA115299NIDDK NIH HHS F32 DK107052NIDDK NIH HHS K01 DK093885NIDDK NIH HHS K01 DK100485NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK056645NIDDK NIH HHS R03 DK114463NIGMS NIH HHS R35 GM124976NIGMS NIH HHS T32 GM008216
Abstract
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we describe a novel interplay between RBPs LIN28B and IMP1 in intestinal epithelial cells. Ribosome profiling and RNA sequencing identified
Indexed as
CarcinogenesisGene Expression RegulationRegulonWnt Signaling PathwayAnimalsCell Line, TumorColorectal NeoplasmsHumansIntestinal MucosaMiceMice, TransgenicOncogenesProtein BiosynthesisRegenerationRNA-Binding ProteinsStem CellsIGF2BP1 protein, humanIMP1 protein, mouseLIN28B protein, humanRNA-Binding ProteinsIMP1intestinal tumorigenesisLIN28Bpost-transcriptional regulationribosome profiling
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.