Evidence map›Paper›PMID 30068697›Full record

ArticleBioscience reports2018

Golgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer.

Yunfei Bai, Xiaobo Cui, Dongxue Gao, Yaping Wang, Boqian Wang, Wei Wang

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Golgi Drivers of Cancer.Sub-cellular biochemistry · 2026
    Review
  3. Monensin suppresses EMT-driven cancer cell motility by inducing Golgi pH-dependent exocytosis of GOLIM4.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. A Mettl16/mThe EMBO journal · 2024
    Article
  8. The Role of Genetic Polymorphisms in Diabetic Retinopathy: Narrative Review.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Overexpression ofOncology letters · 2020
    Article
  15. Golgi Structure and Function in Health, Stress, and Diseases.Results and problems in cell differentiation · 2019
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yunfei BaiInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Xiaobo CuiInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China nmcxb@sina.com.
Dongxue GaoInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Yaping WangInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Boqian WangInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Wei WangInner Mongolia Medical University Affiliated Hospital, Hohhot, Inner Mongolia, People's Republic of China.
Inner Mongolia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of global head and neck cancer has increased markedly in the last 10 years, and its prognosis is poor, which seriously endangers people's life and health. At present, there are few studies on its pathogenesis. Golgi integral membrane protein 4 (GOLIM4) is a major member of the Golgi apparatus transporter complex, and its role in tumor is unclear. The present study found that GOLIM4 was the key target protein downstream of stromal interaction molecule 1 (STIM1), which can inhibit the proliferation of head and neck cancer cells FaDu (human pharyngeal squamous carcinoma cell) and Tca-8113 (human tongue squamous carcinoma cell) with knockdown of GOLIM4 by lentivirus. And the decreased expression of GOLIM4 induced cellular apoptosis. Further experiments revealed that FaDu cell cycle progression was changed after GOLIM4 silence, G

Indexed as

ApoptosisCell CycleCell ProliferationCell Line, TumorGene Expression Regulation, NeoplasticGene Knockdown TechniquesHead and Neck NeoplasmsHumansSquamous Cell Carcinoma of Head and NeckVesicular Transport ProteinsGOLIM4 protein, humanVesicular Transport Proteinsapoptosiscell cycleGOLIM4head and neck cancerproliferation

Identifiers

PMID30068697
PMCPMC6117616
OpenAlexW2885612498

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.