Evidence map›Paper›PMID 30068688›Full record

ReviewEuropean respiratory review : an official journal of the European Respiratory Society2018

Precision medicine in COPD: where are we and where do we need to go?

Venkataramana K Sidhaye, Kristine Nishida, Fernando J Martinez

Open access · diamondAbstract readReview
In one paragraph

Review in European respiratory review : an official journal of the European Respiratory Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. The Evolving Landscape of COPD Typization.Medicina (Kaunas, Lithuania) · 2026
    Review
  10. Multi-omics to study chronic respiratory diseases and viral infections.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  11. A translational view of airway epithelial dysfunction in COPD.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  12. Review
  13. Nonlinear Association Between Weekday Sleep Duration and COPD Risk: Evidence From NHANES 2017-2023.International journal of chronic obstructive pulmonary disease · 2025
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Icenticaftor, Novel Therapy for COPD: This Glass Is Half Full.American journal of respiratory and critical care medicine · 2023
    Article
  19. Leveraging Omics to Predict Chronic Obstructive Pulmonary Disease Exacerbations: The "Immunome".American journal of respiratory and critical care medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Venkataramana K SidhayeDivision of Pulmonary and Critical Care Medicine, Dept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kristine NishidaDivision of Pulmonary and Critical Care Medicine, Dept of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Fernando J MartinezDivision of Pulmonary and Critical Care Medicine, Dept of Medicine, University of Michigan Health System, Ann Arbor, MI, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USMichigan Medicine · US

Funding

Actin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1M
NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS R01 HL124099
6 · The paper itself

Abstract

Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD.

Indexed as

Precision MedicineClinical Decision-MakingEarly DiagnosisGenetic MarkersGenetic Predisposition to DiseaseHumansLungPhenotypePredictive Value of TestsPulmonary Disease, Chronic ObstructiveTreatment OutcomeGenetic Markers

Identifiers

PMID30068688
PMCPMC6156790
OpenAlexW2887349339

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.