SynthesisNeurology2018
Enlarged perivascular spaces and cognition: A meta-analysis of 5 population-based studies.
Abstract readMeta-AnalysisReview
In one paragraph
Synthesis in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- A bibliometric analysis of international publication trends in brain atrophy research (2008-2023).Frontiers in neurology · 2024Pooled it
- The Relationship Between Enlarged Perivascular Spaces and Cognitive Function: A Meta-Analysis of Observational Studies.Frontiers in pharmacology · 2020Pooled it
- Enlarged Perivascular Spaces and Dementia: A Systematic Review.Journal of Alzheimer's disease : JAD · 2019Pooled it
- Quantifying dilated perivascular spaces in children with sickle cell disease.Pediatric blood & cancer · 2024Trial
- Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.Journal of the American Heart Association · 2026Article
- Impaired Glymphatic Function and Post-stroke Cognitive Decline after Intracerebral Hemorrhage: A Serial Neuroimaging Study.Translational stroke research · 2026Article
- Association of MRI-Visible Perivascular Spaces With Longitudinal Cognitive Decline Over a Decade.Neurology · 2026Observational
- Neuroinflammation and blood-brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications.European journal of medical research · 2026Review
- Vascular cognitive impairment and dementia: Prevention, treatments, mechanisms and management options for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Prognostic value of magnetic resonance imaging-visible perivascular spaces in patients with idiopathic normal pressure hydrocephalus.Quantitative imaging in medicine and surgery · 2026Article
- Glymphatic System Dysfunction Associated with Inflammatory Factors in Asymptomatic Neurosyphilis.Current medical imaging · 2026Article
- Border-associated macrophages: an emerging perspective from physiological basis and multi-disease roles to the mechanism of vascular cognitive impairment and dementia.Journal of neuroinflammation · 2025Review
- Leptomeninges: Anatomy, Mechanisms of Disease and Neuroimaging.Neurology international · 2025Review
- MRI markers of cerebrospinal fluid dynamics predict dementia and mediate the impact of cardiovascular risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Relationship Between Cerebral Small Vessel Disease, Sleep Quality, and Cognitive Impairment Among Community-Dwelling Older Adults: Exploring the Role of Glymphatic Function.European journal of neurology · 2025Article
- Association of Enlarged Perivascular Spaces With Early Serum and Neuroimaging Biomarkers of Alzheimer Disease Pathology.Neurology · 2025Article
- Assessing the Global Impact of Brain Small Vessel Disease on Cognition: The Multi-Ethnic Study of Atherosclerosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain.The journal of pain · 2025Article
- A multimodal MRI-based machine learning framework for classifying cognitive impairment in cerebral small vessel disease.Scientific reports · 2025Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Saima HilalFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Chuen Seng TanFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Hieab H H AdamsFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Mohamad HabesFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Vincent MokFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Narayanaswamy VenketasubramanianFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Edith HoferFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
M Kamran IkramFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Jill AbrigoFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Meike W VernooijFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Christopher ChenFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Norbert HostenFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Henry VolzkeFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Hans J GrabeFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
Reinhold SchmidtFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany.
M Arfan IkramFrom the Departments of Radiology and Nuclear Medicine (S.H., H.H.H.A., M.W.V., M.A.I.), Epidemiology (S.H., H.H.H.A., M.K.I., M.W.V., M.A.I.), and Neurology (M.K.I., M.A.I.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Pharmacology (S.H., C.C.), National University of Singapore; Memory, Aging and Cognition Center (S.H., C.C.), National University Health System; Saw Swee Hock School of Public Health (C.S.T.), National University of Singapore; Department of Radiology (M.H.), University of Pennsylvania, Philadelphia; Department of Psychiatry and Psychotherapy (M.H., H.J.G.), Institute for Community Medicine (M.H., H.V., H.J.G.), and Institute of Diagnostic Radiology and Neuroradiology (N.H.), University Medicine Greifswald, Germany; Therese Pei Fong Chow Research Center for Prevention of Dementia (V.M.), LuiChe Woo Institute of Innovative Medicine, Gerald Choa Neuroscience Centre; Department of Medicine and Therapeutics (V.M.) and Department of Imaging & Interventional Radiology (J.A.), Chinese University of Hong Kong, China; Raffles Neuroscience Centre (N.V.), Raffles Hospital, Singapore; Department of Neurology (E.H.), Medical University of Graz, Austria; and German Center for Neurodegenerative Diseases (DZNE) (R.S.), Site Rostock/Greifswald, Germany. m.a.ikram@erasmusmc.nl.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association of enlarged perivascular spaces (ePVS) with cognition in elderly without dementia.
methodsWe included 5 studies from the Uniform Neuro-Imaging of Virchow-Robin Space Enlargement (UNIVRSE) consortium, namely the Austrian Stroke Prevention Family Study, Study of Health in Pomerania, Rotterdam Study, Epidemiology of Dementia in Singapore study, and Risk Index for Subclinical Brain Lesions in Hong Kong study. ePVS were counted in 4 regions (mesencephalon, hippocampus, basal ganglia, and centrum semiovale) with harmonized rating across studies. Mini-Mental State Examination (MMSE) and general fluid cognitive ability factor (G-factor) were used to assess cognitive function. For each study, a linear regression model was performed to estimate the effect of ePVS on MMSE and G-factor. Estimates were pooled across studies with the use of inverse variance meta-analysis with fixed- or random-effect models when appropriate.
resultsThe final sample size consisted of 3,575 persons (age range 63.4-73.2 years, 50.6% women). Total ePVS counts were not significantly associated with MMSE score (mean difference per ePVS score increase 0.001, 95% confidence interval [CI] -0.007 to 0.008,
conclusionsIn this study, we found that ePVS counts were not associated with cognitive dysfunction in the general population. Future studies with longitudinal designs are warranted to examine whether ePVS contribute to cognitive decline.
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AgedBrain EdemaCerebral ArteriesCognition DisordersCommunity Health PlanningFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Tests
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