ArticleScience translational medicine2018
The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling.
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Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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72citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
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Who cites it
72 citing papers in PubMed, 119 citations in OpenAlex.
- Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026Review
- The mMolecular psychiatry · 2026Article
- Anti-asthma drug montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling.Signal transduction and targeted therapy · 2026Article
- Transcriptomic and phenotypic convergence of neurodevelopmental disorder risk genes in vitro and in vivo.Nature neuroscience · 2026Article
- Dysregulated GluA2-Y876 phosphorylation contributes to loss of synaptic upscaling in GRIP1 mutant mice with reduced sociability and increased repetitive behavior.Molecular psychiatry · 2026Article
- Functional implications of polygenic risk for schizophrenia in human neurons.Nature communications · 2026Article
- Memory processing in neurodevelopmental disorders: linking behavioral, circuits, and molecular scales.Frontiers in cellular neuroscience · 2026Review
- Insulin and IGF signaling in the brain: multilevel regulation of synaptic and network homeostasis.Frontiers in endocrinology · 2026Review
- Dynamic convergence of neurodevelopmental disorder risk genes across neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
- Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice.Neurobiology of disease · 2025Article
- Intrinsic adaptive plasticity in mouse and human sensory neurons.The Journal of general physiology · 2025Article
- Deep functional measurements of Fragile X syndrome human neurons reveal multiparametric electrophysiological disease phenotype.Communications biology · 2024Article
- Retinoic acid-mediated homeostatic plasticity in the nucleus accumbens core contributes to incubation of cocaine craving.Psychopharmacology · 2024Article
- An induced pluripotent stem cell line carrying a silencing-resistant calcium reporter allele.Stem cell research · 2024Article
- From wings to whiskers to stem cells: why every model matters in fragile X syndrome research.Journal of neurodevelopmental disorders · 2024Review
- Diverging from the Norm: Reevaluating What Miniature Excitatory Postsynaptic Currents Tell Us about Homeostatic Synaptic Plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Activity-Dependent Transcriptional Program in NGN2+ Neurons Enriched for Genetic Risk for Brain-Related Disorders.Biological psychiatry · 2024Article
- Genetics of human brain development.Nature reviews. Genetics · 2024Review
- Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices.Frontiers in cellular neuroscience · 2024Article
- A human in vitro neuronal model for studying homeostatic plasticity at the network level.Stem cell reports · 2023Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Zhenjie ZhangDepartments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.ORCID 0000-0002-3160-4355
Samuele G MarroDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.ORCID 0000-0002-9326-6945
Yingsha ZhangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.
Kristin L ArendtDepartments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.ORCID 0000-0002-0899-4017
Christopher PatzkeDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.
Bo ZhouDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.
Tyler FairDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.
Nan YangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA. luchen1@stanford.edu wernig@stanford.edu tcs1@stanford.edu.ORCID 0000-0003-3361-9275
Marius WernigDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305-5453, USA. luchen1@stanford.edu wernig@stanford.edu tcs1@stanford.edu.
Lu ChenDepartments of Neurosurgery, and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA. luchen1@stanford.edu wernig@stanford.edu tcs1@stanford.edu.ORCID 0000-0002-8097-2699
California Institute for Regenerative Medicine · USStanford Medicine · USStanford University · USHoward Hughes Medical Institute · US
Funding
Role of synaptotagmins and neurexin ligands in homeostatic synaptic plasticityP50MH086403 · NIMH · STANFORD UNIVERSITY · PI DEISSEROTH, KARL A. · 2009 to 2019
$18.4MMultimodal analysis of high-risk psychosis mutations in induced neuronal cellsU19MH104172 · NIMH · STANFORD UNIVERSITY · PI WERNIG, MARIUS · 2014 to 2018
$9.7MInduced neuronal cells: A novel tool to study neuropsychiatric diseasesR01MH092931 · NIMH · STANFORD UNIVERSITY · PI Thomas C. Sudhof, Marius Wernig · 2010 to 2026
$9.7MVECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2011 to 2019
$6.3MDevelopmental Pathophysiology of Synapses in a Mouse Model of Fragile X SyndromeR01HD084215 · NICHD · STANFORD UNIVERSITY · PI CHEN, LU · 2014 to 2018
$3.3MAPP, Alzheimer's Disease, and Synaptic FunctionR01MH069585 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI SUDHOF, THOMAS C. · 2004 to 2008
$2.6MRegulation of synaptic transmission by retinoic acid signalingR01MH091193 · NIMH · STANFORD UNIVERSITY · PI CHEN, LU · 2011 to 2015
$2.3MNICHD NIH HHS R01 HD084215NIMH NIH HHS P50 MH086403NIMH NIH HHS R01 MH069585NIMH NIH HHS R01 MH091193NIMH NIH HHS R01 MH092931NIMH NIH HHS U19 MH104172NINDS NIH HHS P30 NS069375
Abstract
Fragile X syndrome (FXS) is an X chromosome-linked disease leading to severe intellectual disabilities. FXS is caused by inactivation of the fragile X mental retardation 1 (
Indexed as
HomeostasisNeuronal PlasticitySignal TransductionAllelesAnimalsBase SequenceCell DifferentiationCell LineEmbryonic Stem CellsExcitatory Postsynaptic PotentialsFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeHumansMiceMutationNeuronsFragile X Messenger Ribonucleoprotein 1Tretinoin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.