Evidence map›Paper›PMID 30068546›Full record

ArticleThe Journal of biological chemistry2018

PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (

Sarina R Cameron, Soumyadeep Nandi, Tatyana G Kahn, Juan I Barrasa, Per Stenberg, Yuri B Schwartz

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sarina R CameronFrom the Department of Molecular Biology and.
Soumyadeep NandiFrom the Department of Molecular Biology and.
Tatyana G KahnFrom the Department of Molecular Biology and.
Juan I BarrasaFrom the Department of Molecular Biology and.
Per StenbergFrom the Department of Molecular Biology and.
Yuri B SchwartzFrom the Department of Molecular Biology and yuri.schwartz@umu.se.
Umeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycomb group proteins are essential epigenetic repressors. They form multiple protein complexes of which two kinds, PRC1 and PRC2, are indispensable for repression. Although much is known about their biochemical properties, how mammalian PRC1 and PRC2 are targeted to specific genes is poorly understood. Here, we establish the cyclin D2 (

Indexed as

OncogenesAnimalsBinding SitesCyclin D2Gene SilencingHumansMicePolycomb-Group ProteinsProtein BindingTranscription, GeneticCCND2 protein, humanCyclin D2Polycomb-Group Proteinschromatincyclin D2epigeneticsgene silencingoncogenepolycombpolycomb targetingPRC1

Identifiers

PMID30068546
PMCPMC6139545
OpenAlexW2886163198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.