Trial reportThe Journal of experimental medicine2018
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.
Open access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in The Journal of experimental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2024Pooled it
- Differential STING and p53 expression in epidermodysplasia verruciformis-associated versus non-EV cutaneous squamous cell carcinomas.Medical oncology (Northwood, London, England) · 2026Article
- Lipid flip-flop in biological membranes: through the lens of TMEM16F.Physiological reviews · 2026Review
- Genotype-phenotype correlations and cancer risk in monogenic epidermodysplasia verruciformis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Acquired Epidermodysplasia Verruciformis in Patients with Iatrogenic Immunosuppression.Journal of clinical medicine · 2026Review
- TMC6/8-associated epidermodysplasia verruciformis: germline variants and a complex structural alteration in a skin cancer predisposition syndrome.European journal of human genetics : EJHG · 2026Article
- Human LFA-1 governs T cell immune surveillance of the skin.Science immunology · 2026Article
- Reduced TLR3 and TLR9 Expression in Epidermodysplasia Verruciformis: Evidence From a Comparative Skin Study.Journal of medical virology · 2025Article
- TMC1 and TMC2 are cholesterol-dependent scramblases that regulate membrane homeostasis in auditory hair cells.bioRxiv : the preprint server for biology · 2025Article
- The Role of HPV in the Development of Cutaneous Squamous Cell Carcinoma-Friend or Foe?Cancers · 2025Review
- The monogenic landscape of human infectious diseases.The Journal of allergy and clinical immunology · 2025Review
- The Diverse Functions of the Calcium- and Integrin-Binding Protein Family.International journal of molecular sciences · 2025Review
- Wide-ranging cellular functions of ion channels and lipid scramblases in the structurally related TMC, TMEM16 and TMEM63 families.Nature structural & molecular biology · 2025Review
- MmuPV1 infection of Tmc6/Ever1 or Tmc8/Ever2 deficient FVB mice as a model of βHPV in typical epidermodysplasia verruciformis.PLoS pathogens · 2025Article
- Review
- The Microbe, the Infection Enigma, and the Host.Annual review of microbiology · 2024Review
- Inherited human RelB deficiency impairs innate and adaptive immunity to infection.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Case Report of Two Independent Moroccan Families with Syndromic Epidermodysplasia Verruciformis and STK4 Deficiency.Viruses · 2024Article
- Insights into the genetic theory of infectious diseases.La Tunisie medicale · 2024Review
- Sequence variations and accessory proteins adapt TMC functions to distinct sensory modalities.Neuron · 2024Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
37 authors at 15 institutions in 7 countries.
Sarah Jill de JongSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Amandine CréquerSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Irina MatosRobin Chemers Neustein Laboratory of Mammalian Development and Cell Biology, The Rockefeller University, New York, NY.
David HumSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Vignesh GunasekharanDepartment of Microbiology-Immunology, Northwestern University, Chicago, IL.
Lazaro LorenzoLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, UMR 1163, Necker Hospital for Sick Children, Paris, France.
Fabienne Jabot-HaninLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, UMR 1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-9294-7135
Elias ImahornDepartment of Biomedicine, University Hospital Basel and University of Basel, Switzerland.
Andres A AriasPrimary Immunodeficiencies Group, School of Medicine, University of Antioquia, Medellin, Colombia.ORCID 0000-0002-9478-8403
Hassan VahidnezhadDepartment of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0003-4298-9147
Leila YoussefianDepartment of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0002-4253-6503
Janet G MarkleSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Etienne PatinHuman Evolutionary Genetics, Pasteur Institute, Paris, France.ORCID 0000-0002-9911-4459
Aurelia D'AmicoSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.
Claire Q F WangLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY.
Florian FullClinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Armin EnsserClinical and Molecular Virology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.ORCID 0000-0001-8873-3863
Tina M LeisnerDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Leslie V PariseDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0002-6860-4252
Matthieu BouazizLaboratory of Human Genetics of Infectious Diseases, Institut National de la Santé et de la Recherche Médicale, UMR 1163, Necker Hospital for Sick Children, Paris, France.
Nataly Portilla MayaFundación Universitaria de Ciencias de la Salud, Bogota, Colombia.
Xavier Rueda CadenaDermatology/Oncology - Skin Cancer Unit, National Cancer Institute, Bogota, Colombia.
Bayaki SakaDepartment of Dermatology, Sylvanus Olympio Hospital, University of Lomé, Togo.
Amir Hossein SaeidianDepartment of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0003-3512-0654
Nessa AghazadehDepartment of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Sirous ZeinaliMolecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Peter ItinDepartment of Biomedicine, University Hospital Basel and University of Basel, Switzerland.
James G KruegerLaboratory of Investigative Dermatology, The Rockefeller University, New York, NY.
Lou LaiminsDepartment of Microbiology-Immunology, Northwestern University, Chicago, IL.
Laurent AbelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.ORCID 0000-0001-7016-6493
Elaine FuchsRobin Chemers Neustein Laboratory of Mammalian Development and Cell Biology, The Rockefeller University, New York, NY.
Jouni UittoDepartment of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.ORCID 0000-0003-4639-807X
Jose Luis FrancoPrimary Immunodeficiencies Group, School of Medicine, University of Antioquia, Medellin, Colombia.ORCID 0000-0001-5664-6415
Bettina BurgerDepartment of Biomedicine, University Hospital Basel and University of Basel, Switzerland.ORCID 0000-0002-7686-0176
Gérard OrthDepartment of Virology, Pasteur Institute, Paris, France.
Emmanuelle JouanguySt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY.ORCID 0000-0002-7358-9157
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY casanova@rockefeller.edu.ORCID 0000-0002-7782-4169
Rockefeller University · USInserm · FRThomas Jefferson University · USUniversity of Basel · CHFriedrich-Alexander-Universität Erlangen-Nürnberg · DEInstitut Pasteur · FRNorthwestern University · USPasteur Institute of Iran · IRUniversidad de Antioquia · COUniversity of North Carolina at Chapel Hill · USFundación Universitaria de Ciencias de la Salud · COHoward Hughes Medical Institute · USInstituto Nacional de Cancerología · CORazi Hospital · IRUniversity of Lomé · TG
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MREGULATION OF HUMAN PAPILLOMAVIRUS GENE EXPRESSIONR01CA059655 · NCI · UNIVERSITY OF CHICAGO · PI LAIMINS, LAIMONIS A. · 1993 to 2023
$7.4MRenewal: HPV and the DNA Damage ResponseR01CA142861 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Laimonis A. LAIMINS · 2010 to 2026
$5.2MMolecular genetic dissection of epidermodysplasia verruciformisR21AI107508 · NIAID · ROCKEFELLER UNIVERSITY · PI JOUANGUY, EMMANUELLE · 2014 to 2015
$466kDeveloping therapeutic inhibitors of CIB1 for breast cancerR41CA200189 · NCI · REVERIS THERAPEUTICS, LLC · PI FRYE, STEPHEN VERNON, PARISE, LESLIE · 2015 to 2018
$400kNCATS NIH HHS UL1 TR001866NCI NIH HHS R01 CA059655NCI NIH HHS R01 CA142861NCI NIH HHS R41 CA200189NIAID NIH HHS R21 AI107508
Abstract
Patients with epidermodysplasia verruciformis (EV) and biallelic null mutations of
Indexed as
Immunity, InnateAdultAgedAged, 80 and overBetapapillomavirusCalcium-Binding ProteinsCell AdhesionCell MovementEpidermodysplasia VerruciformisFemaleHuman papillomavirus 16HumansKeratinocytesMaleMembrane ProteinsMiddle AgedCalcium-Binding ProteinsCIB1 protein, humanE5 protein, Human papillomavirus type 6Membrane ProteinsMultiprotein ComplexesOncogene Proteins, ViralTMC6 protein, humanTMC8 protein, human
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.