Evidence map›Paper›PMID 30068479›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2018

Translational Evaluation of Acid/Base and Electrolyte Alterations in Rodent Model of Focal Ischemia.

Sarah R Martha, Lisa A Collier, Stephanie M Davis, Hilary A Seifert, Christopher C Leonardo, Craig T Ajmo, Elspeth A Foran, Justin F Fraser, Keith R Pennypacker

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Sarah R MarthaCollege of Nursing, University of Kentucky, Lexington, Kentucky. Electronic address: sarah.martha@uky.edu.
Lisa A CollierDepartment of Neurology, College of Medicine, University of Kentucky, Lexington, Kentucky.
Stephanie M DavisDepartment of Neurology, College of Medicine, University of Kentucky, Lexington, Kentucky.
Hilary A SeifertDepartment of Neurology, School of Medicine, Oregon Health & Science University, Portland, Oregon.
Christopher C LeonardoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of Southern Florida, Tampa, Florida.
Craig T AjmoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of Southern Florida, Tampa, Florida.
Elspeth A ForanDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of Southern Florida, Tampa, Florida.
Justin F FraserDepartment of Neurology, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Neurosurgery, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Radiology, College of Medicine, University of Kentucky, Lexington, Kentucky.
Keith R PennypackerDepartment of Neurology, College of Medicine, University of Kentucky, Lexington, Kentucky; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, Kentucky.
University of Kentucky · USUniversity of South Florida · USOregon Health & Science University · US

Funding

Anti-Oxidant Promoting Cytokine LIF Enhances Neural Cell Survival During IschemiaR01NS091146 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI PENNYPACKER, KEITH R · 2016 to 2019
$1.4M
Anti-Oxidant Promoting Cytokine LIF Enhances Neural Cell Survival During IschemiaR56NS091146 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI PENNYPACKER, KEITH R · 2015 to 2015
$374k
NINDS NIH HHS R01 NS091146NINDS NIH HHS R56 NS091146
6 · The paper itself

Abstract

background and purposeAcid/base and electrolytes could provide clinically valuable information about cerebral infarct core and penumbra. We evaluated associations between acid/base and electrolyte changes and outcomes in 2 rat models of stroke, permanent, and transient middle cerebral artery occlusion.

methodsThree-month old Sprague-Dawley rats underwent permanent or transient middle cerebral artery occlusion. Pre- and post-middle cerebral artery occlusion venous samples for permanent and transient models provided pH, carbon dioxide, oxygen, glucose, and electrolyte values of ionized calcium, potassium, and sodium. Multiple regression determined predictors of infarct volume from these values, and Kaplan-Meier curve analyzed morality between permanent and transient middle cerebral artery occlusion models.

resultsAnalysis indicated significant differences in the blood gas and electrolytes between pre- to post-middle cerebral artery occlusion. A decrease in pH and sodium with increases in carbon dioxide, potassium, ionized calcium, and glucose changes were found in both middle cerebral artery occlusion models; while hematocrit and hemoglobin were significant in the transient model. pH and ionized calcium were predictors of infarct volume in the permanent model, as changes in pH and ionized calcium decreased, infarct volume increased.

conclusionsThere are acute changes in acid/base balance and electrolytes during stroke in transient and permanent rodent models. Additionally, we found pH and ionized calcium changes predicted stroke volume in the permanent middle cerebral artery occlusion model. These preliminary findings are novel, and warrant further exploration in human conditions.

Indexed as

Acid-Base EquilibriumWater-Electrolyte BalanceAnimalsBiomarkersBlood GlucoseCalciumCarbon DioxideDisease Models, AnimalHemoglobinsHydrogen-Ion ConcentrationInfarction, Middle Cerebral ArteryOxygenPotassiumRats, Sprague-DawleySodiumTime FactorsBiomarkersBlood GlucoseCalciumCarbon DioxideHemoglobinsOxygenPotassiumSodiumacid/base balanceearly blood chemistry changeselectrolytesFocal ischemiainfarct volume

Identifiers

PMID30068479
PMCPMC6139269
OpenAlexW2884459081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.