Evidence map›Paper›PMID 30068419›Full record

ReviewDevelopment and psychopathology2018

Atypical fetal development: Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology.

Michael K Georgieff, Phu V Tran, Erik S Carlson

Abstract readReview
In one paragraph

Review in Development and psychopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Article
  3. Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael K GeorgieffUniversity of Minnesota School of Medicine.
Phu V TranUniversity of Minnesota School of Medicine.
Erik S CarlsonUniversity of Washington School of Medicine.

Funding

Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum DisordersR01AA024123 · NIAAA · UNIVERSITY OF MINNESOTA · PI GEORGIEFF, MICHAEL K., WOZNIAK, JEFFREY ROBERT · 2015 to 2025
$4.6M
NEWBORN IRON DEFICIENCYR01HD029421 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GEORGIEFF, MICHAEL K. · 2000 to 2015
$4.4M
Newborn Iron DeficiencyR01HD094809 · NICHD · UNIVERSITY OF MINNESOTA · PI Michael K. Georgieff · 2018 to 2026
$3.6M
Roles of Iron-Dependent PHD and JARID in Early-Life Iron Deficiency-Induced Adult Neural Gene DysregulationR01NS099178 · NINDS · UNIVERSITY OF MINNESOTA · PI TRAN, PHU V. · 2017 to 2021
$1.6M
Genetic Dissection of Cerebellar Circuitry in Cognitive and Affective BehaviorK08MH104281 · NIMH · UNIVERSITY OF WASHINGTON · PI CARLSON, ERIK SEAN · 2014 to 2017
$727k
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum DisordersR56AA024123 · NIAAA · UNIVERSITY OF MINNESOTA · PI GEORGIEFF, MICHAEL K., WOZNIAK, JEFFREY ROBERT · 2020 to 2020
$154k
NEWBORN IRON DEFICIENCY IN INFANTS OF DIABETIC MOTHERSR29HD029421 · NICHD · UNIVERSITY OF MINNESOTA TWIN CITIES · PI GEORGIEFF, MICHAEL K. · 1995 to 1999
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NIAAA NIH HHS R01 AA024123NIAAA NIH HHS R56 AA024123NICHD NIH HHS R01 HD029421NICHD NIH HHS R01 HD094809NICHD NIH HHS R29 HD029421NIMH NIH HHS K08 MH104281NINDS NIH HHS R01 NS099178
6 · The paper itself

Abstract

Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action.

Indexed as

BrainFemaleFetal Alcohol Spectrum DisordersFetal DevelopmentHumansMalnutritionMental DisordersNeurodevelopmental DisordersPregnancyPrenatal Exposure Delayed EffectsTeratogensTeratogens

Identifiers

PMID30068419
PMCPMC6074054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.