ArticleDevelopment and psychopathology2018
Testing the programming of temperament and psychopathology in two independent samples of children with prenatal substance exposure.
Article in Development and psychopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The impact of prenatal maternal stress due to potentially traumatic events on child temperament: A systematic review.Developmental psychobiology · 2021Pooled it
- The Influences of Drug Abuse on Mother-Infant Interaction Through the Lens of the Biopsychosocial Model of Health and Illness: A Review.Frontiers in public health · 2019Pooled it
- Neural correlates of child temperament: The role of brain network connectivity in psychopathology risk.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Comparing the effectiveness of master's-level clinicians and peer supports for the delivery of attachment and biobehavioral catchup.Journal of clinical and translational science · 2026Article
- From Distress To Disruption in Early Childhood: Time-Varying Associations Between Internalizing and Externalizing Problems, Child Sex and Prenatal Cocaine Exposure.Research on child and adolescent psychopathology · 2025Article
- Developmental cascades from maternal preconception stress to child behavior problems: Testing multilevel preconception, prenatal, and postnatal influences.Developmental psychology · 2024Article
- Temperament and psychopathology: The "community" to which you belong matters.Child development · 2022Article
- Child temperament and child-teacher relationship quality: Implications for children's emotional functioning during preschool period.Frontiers in psychology · 2022Article
- Article
- The centrality of temperament to the research domain criteria (RDoC): The earliest building blocks of psychopathology.Development and psychopathology · 2021Article
- Prenatal substance exposure and maternal hostility from pregnancy to toddlerhood: Associations with temperament profiles at 16 months of age.Development and psychopathology · 2021Article
- Infant Temperament Profiles, Cultural Orientation, and Toddler Behavioral and Physiological Regulation in Mexican-American Families.Child development · 2021Article
- Perinatal foundations of personality pathology from a dynamical systems perspective.Current opinion in psychology · 2021Review
- Prenatal risk factors for internalizing and externalizing problems in childhood.World journal of pediatrics : WJP · 2020Review
- Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring.Psychological medicine · 2020Article
- Perinatal complications are associated with social anxiety: Indirect effects through temperament.Infant and child developmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Prenatal programming models have rarely been applied to research on children with prenatal substance exposure, despite evidence suggesting that prenatal drug exposure is a form of stress that impacts neurodevelopmental outcomes and risk for psychopathology. Utilizing data from two longitudinal multisite studies comprising children prenatally exposed to substances as well as a nonexposed comparison group (Maternal Lifestyle Study, n = 1,388; Infant Development, Environment, and Lifestyle study, n = 412), we tested whether early phenotypic indicators of hypothesized programming effects, indexed by growth parameters at birth and infant temperament, served as a link between prenatal substance exposure and internalizing and externalizing behavior at age 5. Latent profile analysis indicated that individual differences in reactivity and regulation for infants prenatally exposed to substances was best characterized by four temperament profiles. These profiles were virtually identical across two independent samples, and demonstrated unique associations with adjustment difficulties nearly 5 years later. Results of path analysis using structural equation modeling also showed that increased prenatal substance exposure was linked to poorer growth parameters at birth, profiles of temperamental reactivity in infancy, and internalizing and externalizing behavior at age 5. This pathway was partially replicated across samples. This study was among the first to link known individual-level correlates of prenatal substance exposure into a specific pathway to childhood problem behavior. Implications for the developmental origins of a child's susceptibility to psychopathology as a result of intrauterine substance exposure are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.