ArticleDevelopment and psychopathology2018
Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence.
Article in Development and psychopathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders.Genome biology · 2021Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- Interpersonal stress, epigenetic indices of inflammation, and depressive symptoms: Longitudinal associations from adolescence to young adulthood.Neurobiology of stress · 2026Article
- Protein epigenetic scores derived in neonatal saliva as biomarkers of childhood cognition.Molecular psychiatry · 2026Article
- Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population-based cohorts.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Polygenic score for C-reactive protein is linked to faster cortical thinning and psychopathology risk in adolescents.Nature. Mental health · 2026Article
- Interplay between the HPA axis and inflammation as mechanisms therapeutic targets ofFrontiers in pharmacology · 2026Review
- Child and adolescent internalizing and externalizing traits, and epigenetic summary scores: A scoping review.Biological psychology · 2025Article
- Maternal history of maltreatment interacts with DNA methylation patterns to predict infant temperament.Child abuse & neglect · 2025Article
- Cross-omics risk scores of inflammation markers are associated with all-cause mortality: The Canadian Longitudinal Study on Aging.American journal of human genetics · 2025Article
- Epigenetic clocks and DNA methylation biomarkers of brain health and disease.Nature reviews. Neurology · 2025Review
- Dissecting biological heterogeneity in major depressive disorder based on neuroimaging subtypes with multi-omics data.Translational psychiatry · 2025Article
- Associations between inflammation and striatal dopamine D2-receptor availability in aging.Journal of neuroinflammation · 2025Article
- Associations between prenatal stress with offspring inflammation, depression and anxiety.Psychoneuroendocrinology · 2024Article
- Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation - A longitudinal population-based study.Brain, behavior, and immunity · 2024Article
- Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study.Brain, behavior, and immunity · 2024Article
- Associations of DNA-methylation measures of biological aging with social disparities in child and adolescent mental health.Clinical psychological science : a journal of the Association for Psychological Science · 2024Article
- Epigenetic scores derived in saliva are associated with gestational age at birth.Clinical epigenetics · 2024Article
- Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts.Cell genomics · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.
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