ArticleVirology journal2018
Phylogenetic analysis of the wild-type strains of canine distemper virus circulating in the United States.
Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Geographical Distribution of Carnivore Hosts and Genotypes of Canine Distemper Virus (CDV) Worldwide: A Scoping Review and Spatial Meta-Analysis.Transboundary and emerging diseases · 2025Pooled it
- Molecular and serological surveys of canine distemper virus: A meta-analysis of cross-sectional studies.PloS one · 2019Pooled it
- Circulation of arctic canine distemper virus in diarrheic dogs in Iran: molecular detection and phylogenetic characterization.BMC research notes · 2026Article
- Investigating the evolution of the Arctic lineage of canine distemper virus circulating in Italy.Veterinary research · 2026Article
- Synthesizing selection mosaic theory and host-pathogen theory to explain large-scale pathogen coexistence.Nature communications · 2025Article
- mRNA-LNP vaccine encoding CDV hemagglutinin confers effective protection in raccoon dogs.NPJ vaccines · 2025Article
- Article
- Phylogenetic and sequence analysis of the co-circulating lineages in the canine distemper virus complexity from Northern Vietnam (2017-2023).Veterinary research communications · 2025Article
- Article
- Canine distemper virus phylogenetic structure and ecological correlates of infection in mesocarnivores across anthropogenic land use gradients.Microbiology spectrum · 2025Article
- Article
- Study of Canine Distemper Virus Presence in Catalonia's Wild Carnivores through H Gene Amplification and Sequencing.Animals : an open access journal from MDPI · 2024Article
- Identification of a new polymorphism on the wild-type canine distemper virus genome: could this contribute to vaccine failures?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Article
- Structure and function of a novel lineage-specific neutralizing epitope on H protein of canine distemper virus.Frontiers in microbiology · 2022Article
- Canine Morbillivirus from Colombian Lineage Exhibits In Silico and In Vitro Potential to Infect Human Cells.Pathogens (Basel, Switzerland) · 2021Article
- Myocarditis caused by naturally acquired canine distemper virus infection in 4 dogs.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Identifying Candidate Genetic Markers of CDV Cross-Species Pathogenicity in African Lions.Pathogens (Basel, Switzerland) · 2020Article
- Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia.Pathogens (Basel, Switzerland) · 2019Article
- Phylogenetic evidence of the intercontinental circulation of a Canine distemper virus lineage in the Americas.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCanine distemper (CD) is a highly contagious, systemic, viral disease of dogs seen worldwide. Despite intensive vaccination in developed countries, recent reports suggest both the re-emergence and increased activity of Canine distemper virus (CDV) worldwide, including the United States. CDV is an RNA virus of the genus Morbillivirus within the family Paramyxoviridae. Viral genomic RNA encodes six structural proteins. Of the six structural proteins, the hemagglutinin (H) gene has the greatest genetic variation and is therefore a suitable target for molecular epidemiological studies. The majority of neutralizing epitopes are found on the H protein, making this gene also important for evaluation of changes over time that may result in antigenic differences among strains. The aim of this study was to determine the phylogenetic relationship of CDV strains circulating in the US.
methodsFifty-nine positive canine distemper virus samples collected from dogs from different regions and states from 2014 to 2017 were sequenced with a targeted next-generation sequencing (NGS) method. The sequences of the H, F, and P genes and the matrix-fusion (M-F) intergenic region of the amplified CDVs were analyzed individually.
resultsSequence analysis of the H gene revealed that there are at least 3 different lineages of CDV currently circulating in the US. These lineages include America-3 (Edomex), America-4, and a clade that was previously reported in association with an outbreak in Wyoming, which was linked to a domestic dog-breeding facility in Kansas in 2010. These lineages differ from the historically identified lineages in the US, including America-1, which contains the majority of the vaccine strains. Genetic differences may result in significant changes to the neutralizing epitopes that consequently may lead to vaccine failure. Phylogenetic analyses of the nucleotide sequences obtained in this study of the F and P genes and the M-F intergenic region with sequences from the GenBank database produced similar findings to the H gene analysis.
conclusionsThe CDV lineages currently circulating in the US differ from the historically identified lineages America-1. Continuous surveillance is required for monitoring circulating CDV strains in the US, to prevent potential vaccine breakthrough events.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.