ArticleBMC biology2018
Naked mole-rat transcriptome signatures of socially suppressed sexual maturation and links of reproduction to aging.
Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Eusocial reproduction selects for longevity.bioRxiv : the preprint server for biology · 2026Article
- Resistance to age-related hypercoagulability: insights from the naked mole rat.Research and practice in thrombosis and haemostasis · 2026Article
- In vitro production of naked mole-rats' blastocysts from non-breeding females using in vitro maturation and intracytoplasmic sperm injection.Scientific reports · 2023Article
- Reproductive Suppression Caused by Spermatogenic Arrest: Transcriptomic Evidence from a Non-Social Animal.International journal of molecular sciences · 2023Article
- Comparative analysis of thyroid hormone systems in rodents with subterranean lifestyle.Scientific reports · 2023Article
- Postnatal oogenesis leads to an exceptionally large ovarian reserve in naked mole-rats.Nature communications · 2023Article
- Comparative analysis of microRNA and messengerRNA expression profiles in plateau zokor testicular cells under reproductive suppression.Frontiers in veterinary science · 2023Article
- Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.Communications biology · 2022Article
- Stress in an underground empire.Biology letters · 2022Review
- DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders.Nature aging · 2022Article
- Morphological and genomic shifts in mole-rat 'queens' increase fecundity but reduce skeletal integrity.eLife · 2021Article
- Abundance and size of hyaluronan in naked mole-rat tissues and plasma.Scientific reports · 2021Article
- Article
- Alternative Animal Models of Aging Research.Frontiers in molecular biosciences · 2021Review
- Eusociality and Senescence: Neuroprotection and Physiological Resilience to Aging in Insect and Mammalian Systems.Frontiers in cell and developmental biology · 2021Review
- Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging.BMC biology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNaked mole-rats (NMRs) are eusocially organized in colonies. Although breeders carry the additional metabolic load of reproduction, they are extremely long-lived and remain fertile throughout their lifespan. This phenomenon contrasts the disposable soma theory of aging stating that organisms can invest their resources either in somatic maintenance, enabling a longer lifespan, or in reproduction, at the cost of longevity. Here, we present a comparative transcriptome analysis of breeders vs. non-breeders of the eusocial, long-lived NMR vs. the polygynous and shorter-lived guinea pig (GP).
resultsComparative transcriptome analysis of tissue samples from ten organs showed, in contrast to GPs, low levels of differentiation between sexes in adult NMR non-breeders. After transition into breeders, NMR transcriptomes are markedly sex-specific, show pronounced feedback signaling via gonadal steroids, and have similarities to reproductive phenotypes in African cichlid fish, which also exhibit social status changes between dominant and subordinate phenotypes. Further, NMRs show functional enrichment of status-related expression differences associated with aging. Lipid metabolism and oxidative phosphorylation-molecular networks known to be linked to aging-were identified among most affected gene sets. Remarkably and in contrast to GPs, transcriptome patterns associated with longevity are reinforced in NMR breeders.
conclusionOur results provide comprehensive and unbiased molecular insights into interspecies differences between NMRs and GPs, both in sexual maturation and in the impact of reproduction on longevity. We present molecular evidence that sexual maturation in NMRs is socially suppressed. In agreement with evolutionary theories of aging in eusocial organisms, we have identified transcriptome patterns in NMR breeders that-in contrast to the disposable soma theory of aging-may slow down aging rates and potentially contribute to their exceptional long life- and healthspan.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.