ArticleThe American journal of psychiatry2018
Medications for Alcohol and Opioid Use Disorders and Risk of Suicidal Behavior, Accidental Overdoses, and Crime.
Article in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- Personality disorders, violence and antisocial behaviour: updated systematic review and meta-regression analysis.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- Perspectives on medication for opioid use disorder (MOUD) access and service delivery among a community sample of people who use opioids in Los Angeles.Journal of substance use and addiction treatment · 2025Article
- Medicines used in the treatment of opioid dependence.Australian prescriber · 2025Review
- Predictors of Suicidal Ideation and Continued Substance Use Problems Among Patients Receiving Methadone Maintenance Treatment Who Have Co-Occurring Cocaine Use Disorder.Substance use & misuse · 2024Article
- Pharmacologic Approaches to Suicide Prevention.Focus (American Psychiatric Publishing) · 2023Review
- Cost-effectiveness of office-based buprenorphine treatment for opioid use disorder.Drug and alcohol dependence · 2023Article
- The association between buprenorphine treatment duration and mortality: a multi-site cohort study of people who discontinued treatment.Addiction (Abingdon, England) · 2023Article
- Cause-Specific Mortality among Patients in Treatment for Opioid Use Disorder in Multiple Settings: A Prospective Comparative Cohort Study.European addiction research · 2023Article
- Non-fatal overdose risk during and after opioid agonist treatment: A primary care cohort study with linked hospitalisation and mortality records.The Lancet regional health. Europe · 2022Article
- Association between clinically recognized suicidality and subsequent initiation or continuation of medications for opioid use disorder.Drug and alcohol dependence · 2022Article
- Real-world effectiveness of pharmacological treatments of opioid use disorder in a national cohort.Addiction (Abingdon, England) · 2022Article
- Suicidal motivations among opioid overdose survivors: Replication and extension.Drug and alcohol dependence · 2022Article
- Using Mindfulness-Based Cognitive Therapy to Prevent Suicide among High Suicide Risk Patients who also Misuse Opioids: A Preliminary Probe of Feasibility and Effectiveness.International journal of mental health and addiction · 2022Article
- Opioid mortality, public health care expenditures, and cross-national homicide rates: findings from 25 OECD countries, 2000-2017.Social psychiatry and psychiatric epidemiology · 2022Article
- A Buprenorphine Program Evaluation Before and During the COVID-19 Pandemic.The journal for nurse practitioners : JNP · 2022Article
- Use of central nervous system drugs in combination with selective serotonin reuptake inhibitor treatment: A Bayesian screening study for risk of suicidal behavior.Frontiers in psychiatry · 2022Article
- A qualitative study of emergency department patients who survived an opioid overdose: Perspectives on treatment and unmet needs.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2021Article
- A cross-sectional study of opioid involvement in non-poisoning suicide - risks and prevention opportunities.BMC public health · 2021Article
- Article
- Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders.Current addiction reports · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors examined associations between medications for alcohol and opioid use disorders (acamprosate, naltrexone, methadone, and buprenorphine) and suicidal behavior, accidental overdoses, and crime.
methodIn this total population cohort study, 21,281 individuals who received treatment with at least one of the four medications between 2005 and 2013 were identified. Data on medication use and outcomes were collected from Swedish population-based registers. A within-individual design (using stratified Cox proportional hazards regression models) was used to compare rates of suicidal behavior, accidental overdoses, and crime for the same individuals during the period when they were receiving the medication compared with the period when they were not.
resultsNo significant associations with any of the primary outcomes were found for acamprosate. For naltrexone, there was a reduction in the hazard ratio for accidental overdoses during periods when individuals received treatment compared with periods when they did not (hazard ratio=0.82, 95% CI=0.70, 0.96). Buprenorphine was associated with reduced arrest rates for all crime categories (i.e., violent, nonviolent, and substance-related) as well as reduction in accidental overdoses (hazard ratio=0.75, 95% CI=0.60, 0.93). For methadone, there were significant reductions in the rate of suicidal behaviors (hazard ratio=0.60, 95% CI=0.40-0.88) as well as reductions in all crime categories. However, there was an increased risk for accidental overdoses among individuals taking methadone (hazard ratio=1.25, 95% CI=1.13, 1.38).
conclusionsMedications currently used to treat alcohol and opioid use disorders also appear to reduce suicidality and crime during treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.