Evidence map›Paper›PMID 30067987›Full record

ArticleCell reports2018

Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome.

Burcu Guner-Ataman, Juan Manuel González-Rosa, Harsh N Shah, Vincent L Butty, Spencer Jeffrey, Maryline Abrial, Laurie A Boyer, C Geoffrey Burns, Caroline E Burns

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  11. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Burcu Guner-AtamanCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Juan Manuel González-RosaCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Harsh N ShahCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Vincent L ButtyDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Spencer JeffreyCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Maryline AbrialCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Laurie A BoyerDepartment of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
C Geoffrey BurnsCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: gburns@cvrc.mgh.harvard.edu.
Caroline E BurnsCardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: cburns6@mgh.harvard.edu.
Harvard University · USMassachusetts General Hospital · USMassachusetts Institute of Technology · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9M
Change of InstitutionR35HL135831 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, CAROLINE E · 2017 to 2023
$4.2M
Genetic Determinants of Outflow Tract MorphogenesisR01HL096816 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BURNS, C. GEOFFREY · 2010 to 2014
$2.2M
NCI NIH HHS P30 CA014051NHLBI NIH HHS R01 HL096816NHLBI NIH HHS R35 HL135831
6 · The paper itself

Abstract

Microdeletions involving TBX1 result in variable congenital malformations known collectively as 22q11.2 deletion syndrome (22q11.2DS). Tbx1-deficient mice and zebrafish recapitulate several disease phenotypes, including pharyngeal arch artery (PAA), head muscle (HM), and cardiac outflow tract (OFT) deficiencies. In zebrafish, these structures arise from nkx2.5

Indexed as

Cell Differentiation22q11 Deletion SyndromeAnimalsCell LineageEmbryonic Stem CellsHomeobox Protein Nkx-2.5PharynxPhenotypeT-Box Domain ProteinsZebrafishZebrafish ProteinsHomeobox Protein Nkx-2.5Nkx2.5 protein, zebrafishT-Box Domain ProteinsTbx1 protein, zebrafishZebrafish Proteins22q11arch arterycardiopharyngealDiGeorgeheartnkx2.5progenitorTbx1zebrafish

Identifiers

PMID30067987
PMCPMC6261257
OpenAlexW2887289712

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.