Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

1. Mitochondria and lysosomes in T cell immunometabolism.Trends in immunology · 2025
   Review
2. Defective autophagy and autophagy activators in myasthenia gravis: a rare entity and unusual scenario.Autophagy · 2024
   Review
3. Autophagy-enhancing ATG16L1 polymorphism is associated with improved clinical outcome and T-cell immunity in chronic HIV-1 infection.Nature communications · 2024
   Article
4. Research progress of T cell autophagy in autoimmune diseases.Frontiers in immunology · 2024
   Review
5. Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP.Frontiers in medicine · 2024
   Review
6. Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies.Molecular cancer · 2023
   Review
7. Proteostasis in T cell aging.Seminars in immunology · 2023
   Review
8. Machine learning and single-cell sequencing reveal the potential regulatory factors of mitochondrial autophagy in the progression of gastric cancer.Journal of cancer research and clinical oncology · 2023
   Article
9. Streptococcal Arginine Deiminase Inhibits T Lymphocyte Differentiation In Vitro.Microorganisms · 2023
   Article
10. Harnessing Autophagy to Overcome Antigen-Specific T-Cell Dysfunction: Implication for People Living with HIV-1.International journal of molecular sciences · 2023
    Review
11. Autophagic-Related Proteins in Brain Gliomas: Role, Mechanisms, and Targeting Agents.Cancers · 2023
    Review
12. Crosstalk between autophagy and metabolic regulation of (CAR) T cells: therapeutic implications.Frontiers in immunology · 2023
    Review
13. Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation.Nature communications · 2022
    Article
14. A guide to membrane atg8ylation and autophagy with reflections on immunity.The Journal of cell biology · 2022
    Article
15. Notch1 Modulation of Cellular Calcium Regulates Mitochondrial Metabolism and Anti-Apoptotic Activity in T-Regulatory Cells.Frontiers in immunology · 2022
    Article
16. The Role of Autophagy in the Function of CD4Frontiers in pharmacology · 2022
    Review
17. The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment.Frontiers in immunology · 2022
    Review
18. Interactions of Autophagy and the Immune System in Health and Diseases.Autophagy reports · 2022
    Article
19. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.Developmental cell · 2021
    Article
20. Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.Autophagy · 2021
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

9 authors at 2 institutions in 2 countries.

Funding

Abstract

Indexed as