Evidence map›Paper›PMID 30067970›Full record

ArticleCell reports2018

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8

Ioannis D Dimitriou, Korris Lee, Itoro Akpan, Evan F Lind, Valarie A Barr, Pamela S Ohashi, Lawrence E Samelson, Robert Rottapel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.International journal of molecular sciences · 2021
    Article
  6. Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  7. Cells · 2019
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Ioannis D DimitriouPrincess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada.
Korris LeePrincess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada.
Itoro AkpanLaboratory of Cellular and Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.
Evan F LindDepartment of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, OR 97239, USA.
Valarie A BarrLaboratory of Cellular and Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.
Pamela S OhashiCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1L7, Canada.
Lawrence E SamelsonLaboratory of Cellular and Molecular Biology, Center for Cancer Research (CCR), National Cancer Institute (NCI), NIH, Bethesda, MD 20892, USA.
Robert RottapelPrincess Margaret Cancer Center, Toronto Medical Discovery Tower, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1L7, Canada; Department of Medicine, University of Toronto, Toronto, ON M5S 1L7, Canada. Electronic address: rottapel@gmail.com.
Princess Margaret Cancer Centre · CACenter for Cancer Research · USNational Cancer Institute · USOregon Health & Science University · USUniversity of Toronto · CA

Funding

Confocal Core for the Laboratory of Cellular and Molecular BiologyZICBC010978 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PALLIKKUTH, SANDEEP · 2009 to 2025
$7.6M
BIOCHEMICAL BASIS OF T CELL ACTIVATIONZ01BC010304 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SAMELSON, LAWRENCE E · 1999 to 2008
$2.6M
CIHR 143230Intramural NIH HHS Z01 BC010304
6 · The paper itself

Abstract

Successful anti-viral response requires the sustained activation and expansion of CD8

Indexed as

Cell ProliferationAdaptor Proteins, Signal TransducingAnimalsCD8-Positive T-LymphocytesCell DifferentiationCells, CulturedHumansJurkat CellsLymphocyte ActivationMiceReceptors, Antigen, T-CellSignal TransductionAdaptor Proteins, Signal TransducingReceptors, Antigen, T-CellSh3bp2 protein, mouse3BP2CD8(+) T cellsdifferentiationmicroclustersproliferationTCR signaling

Identifiers

PMID30067970
PMCPMC6701191
OpenAlexW2885460059

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.