ArticlePloS one2018
Cognitive deficits in fibromyalgia syndrome are associated with pain responses to low intensity pressure stimulation.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Efficacy and safety of TNX-102 SL in patients with fibromyalgia: a systematic review and meta-analysis.Pain management · 2025Pooled it
- Planning and Problem-Solving Impairments in Fibromyalgia: The Predictive Role of Updating, Inhibition, and Mental Flexibility.Journal of clinical medicine · 2025Article
- Cognitive Reserve and Its Associations with Pain, Anxiety, and Depression in Patients with Chronic Migraine: A Retrospective Study.Journal of clinical medicine · 2025Article
- Quantitative Sensory Testing in Fibromyalgia Syndrome: A Scoping Review.Biomedicines · 2025Review
- Migraine and cognitive dysfunction: a narrative review.The journal of headache and pain · 2024Review
- Attentional deficits in fibromyalgia: an ERP study with the oddball dual task and emotional stroop task.BMC psychology · 2024Article
- A Comparative Analysis of Cognitive Deficits in Rheumatoid Arthritis and Fibromyalgia: Impact of Symptoms Severity and Its Clinical Implications.Psychology research and behavior management · 2024Article
- Mind the Mood: Momentary Depression and Anxiety Moderate the Correspondence Between Subjective and Objective Cognitive Functioning in Fibromyalgia.Arthritis care & research · 2023Article
- Psychoeducation for Fibromyalgia Syndrome: A Systematic Review of Emotional, Clinical and Functional Related-Outcomes.Behavioral sciences (Basel, Switzerland) · 2023Review
- Understanding the Experience and Impacts of Brain Fog in Chronic Pain: A Scoping Review.Canadian journal of pain = Revue canadienne de la douleur · 2023Article
- Decision Making and Fibromyalgia: A Systematic Review.Brain sciences · 2022Review
- Chronic Pain: Clinical Updates and Perspectives.Journal of clinical medicine · 2022Article
- Fibromyalgia Syndrome and Cognitive Decline: The Role of Body Mass Index and Clinical Symptoms.Journal of clinical medicine · 2022Article
- Distress as a mediator for pain and activities of daily living in older adults with fibromyalgia.Frontiers in medicine · 2022Article
- Revealing the Role of Social Support on Cognitive Deficits in Fibromyalgia Syndrome.Behavioural neurology · 2022Article
- Personalized behavior management as a replacement for medications for pain control and mood regulation.Scientific reports · 2021Article
- Review
- Article
- Working Memory Performance, Pain and Associated Clinical Variables in Women With Fibromyalgia.Frontiers in psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFibromyalgia syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain and diffuse tenderness, accompanied by complaints including morning stiffness, fatigue, insomnia and affective symptoms. In addition, affected patients frequently experience cognitive impairments such as concentration difficulties, forgetfulness or problems in planning and decision-making. These deficits are commonly ascribed to interference between nociceptive and cognitive processing.
methodThe present study investigated the association of cognitive performance with (a) pain responses to low intensity pressure stimulation (0.45-2.25 kg/cm2), (b) responses to stronger (above-threshold) stimulation (2.70 kg/cm2), and (c) pain threshold and tolerance in 42 women with FMS. Tests of attention, memory, processing speed, and executive functions were applied.
resultsWhile no significant correlations were seen for pain threshold and pain tolerance, inverse associations arose between pain intensity ratings during pressure stimulation and performance in all evaluated cognitive domains. The magnitude of the correlations increased with decreasing stimulus intensity.
conclusionsIt may be concluded that pain experience during somatosensory stimulation of low intensity is more closely related to attention, memory and executive functions in FMS than the traditional measures of pain threshold and pain tolerance. Considering that pain responses to low intensity stimulation reflect the hyperalgesia and allodynia phenomena characterizing FMS, it may be hypothesized that central nervous pain sensitization is involved in cognitive impairments in the disorder.
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