ArticlePloS one2018
Rapid on-site dual optical system to measure specific reactive oxygen species (O2-• and OCl-) in a tiny droplet of whole blood.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Changes in Whole-Blood microRNA Profiles during the Onset and Treatment Process of Cerebral Infarction: A Human Study.International journal of molecular sciences · 2020Trial
- Dietary 5-aminolevulinic acid modulates gut microbiota, reduces oxidative stress, and enhances immune status in weanling piglets: An 8-week exploratory study.Veterinary world · 2026Article
- Capturing systemic inflammation in a nonhuman primate using a new leukocyte activity assessment system.Journal of clinical biochemistry and nutrition · 2025Article
- Rapid bedside measurement of reactive oxygen species in neonates: a pilot study.Frontiers in pediatrics · 2025Article
- Estimation of reference interval for neutrophil activity evaluation systems: a interim report.Journal of clinical biochemistry and nutrition · 2024Article
- Effect of fat ingestion on postprandial oxidative status in healthy young women: a pilot study.Journal of clinical biochemistry and nutrition · 2024Article
- Comparison of the oxidative profiles before and after revascularization in peripheral arterial disease: a pilot study.Journal of clinical biochemistry and nutrition · 2023Article
- Correlation between human health and reactive oxygen species produced in blood: a long-term chemiluminescence and fluorescence analysis.Scientific reports · 2021Article
- Neutrophils initiate and exacerbate Stevens-Johnson syndrome and toxic epidermal necrolysis.Science translational medicine · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has been implicated in various disorders and controlling it would be important for healthy life. We have developed a new optical system for easily and accurately measuring oxidative stress in whole blood. It is optimized for simultaneously detecting reactive oxygen species (ROS) and highly reactive ROS (hROS), elicited mostly by white blood cells in a few microliters of blood. Results obtained by using this system show at least four important findings. 1) chemiluminescence of MCLA was confirmed to be attributable to O2-•. 2) PMA-stimulated cells released O2-• longer and more slowly than fMLP-stimulated ones. 3) fluorescence produced by APF oxidation was confirmed to be attributable to hROS, mostly OCl-, produced by myeloperoxidase. 4) the generation of OCl- was found to be a slower process than the O2-• generation. We also conducted pilot studies of oxidative stress in healthy volunteers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.