ArticlePloS one2018
Effectiveness of physically ablative and pharmacological treatments for anal condyloma in HIV-infected men.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Clinical guideline for the diagnosis and treatment of cutaneous warts (2022).Journal of evidence-based medicine · 2022Guideline
- Benign lesions prolapsing through the anus: a differential diagnostic algorithm and evidence-based surgical management-a narrative review.Frontiers in surgery · 2026Review
- Intralesional Vitamin D3 for Anogenital Warts in Human Immunodeficiency Virus Infected Individual.International medical case reports journal · 2025Article
- Complete Regression of Anogenital Warts Following Intralesional Measles-Mumps-Rubella (MMR) Vaccine: A Case of Two.Clinical, cosmetic and investigational dermatology · 2025Article
- Detecting and genotyping high-risk human papillomavirus among male patients during 2015-2023 in Beijing, China.Emerging microbes & infections · 2024Article
- Risk of developing high-grade squamous intraepithelial lesions or anal cancer after anal condylomata treatment in people living with HIV.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2024Article
- Pleasurable and problematic receptive anal intercourse and diseases of the colon, rectum and anus.Nature reviews. Gastroenterology & hepatology · 2024Review
- A Case of Genital and Extragenital Warts Unresponsive to Immunotherapy Using Measles, Mumps, Rubella Vaccine.International medical case reports journal · 2023Article
- The Effectiveness of Chemical Cautery and Electrosurgery on Anogenital Wart: Systematic Review.Clinical, cosmetic and investigational dermatology · 2023Review
- Risk factors of oncogenic HPV infection in HIV-positive men with anal condyloma acuminata in Shenzhen, Southeast China: a retrospective cohort study.Frontiers in public health · 2023Article
- Correlation between recurrence of anorectal condyloma acuminatum and human papilloma virus subtype.Genes & genomics · 2022Article
- Male papillomavirus infection and genotyping in the Qingyuan area.Virology journal · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men.
aimTo provide data on the effectiveness of electrosurgical excision, infrared coagulation and pharmacological (imiquimod) treatments for anal condyloma acuminata (peri-anal and/or intra-anal) in HIV-1-infected men based on authors' practice.
methodsSingle-center, retrospective descriptive analysis of HIV-1-infected men, 18 years or older treated for anal condyloma acuminata. Standard treatments were offered: electrosurgery excision, infrared coagulation and topical imiquimod. Effectiveness was evaluated by the recurrence rate at 1 year after treatment. Recurrence was defined as any anal condyloma acuminata diagnosed after 3 months of condyloma-free survival post-treatment. Anal cytology and human-papillomavirus-infection (HPV) was assessed.
resultsBetween January 2005 and May 2009, 101 men were treated for anal condyloma acuminata: 65 (64%) with electrosurgery, 27 (27%) with infrared coagulation and 9 (9%) with imiquimod. At 1 year after treatment, the cumulative recurrence rate was 8% (4/65, 95%CI: 2-15%) with electrosurgery excision, 11% (3/27, 95%CI: 4-28%) with infrared coagulation and 11% (1/9, 95%CI: 2-44%) with imiquimod treatment. No predictive factors were associated with recurrence. Anal HPV-6 or HPV-11 was detectable in 98 (97%) patients and all had high-risk HPV genotypes, and 89 (88%) patients had abnormal anal canal cytology. Limitations: this was a retrospective descriptive analysis; limited to a single center; it cannot know if the recurrence is related to new infection.
conclusionRecurrence of anal condyloma after any treatment was common. Abnormal anal cytology and high-risk HPV-infection were highly prevalent in this population, therefore at high-risk of anal cancer, and warrants careful follow-up.
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