ArticleAutophagy2018
Plasmodium protein UIS3 protects the parasite from autophagy clearance.
Article in Autophagy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- STAT1-IFITM3 promotes autophagy in epithelial cells to controlLife science alliance · 2025Article
- ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation ofFrontiers in immunology · 2023Article
- Autophagy Pathways in the Genesis ofLife (Basel, Switzerland) · 2022Article
- The interplay between pathogens and Atg8 family proteins: thousand-faced interactions.FEBS open bio · 2021Review
- The excretory/secretory products of fifth-stage larval Angiostrongylus cantonensis induces autophagy via the Sonic hedgehog pathway in mouse brain astrocytes.PLoS neglected tropical diseases · 2020Article
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2 authors.
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Abstract
The malaria causative parasite, Plasmodium, has received intense focus due to its complex life cycle and threat to human health. When infecting human hepatocytes, the parasite manages to escape clearance by macroautophagy/autophagy. In a recent paper by Real et al., the authors discovered that the parasitophorous vacuole (PV) membrane protein UIS3 encoded by Plasmodium interacts with MAP1LC3/LC3, an important component of the autophagy machinery. This interaction interferes with the association between LC3 and its receptors, which helps the parasite avoid sequestration by a phagophore, and subsequent elimination by the host. This study expands our knowledge about the Plasmodium-host interaction, as well as provides information for a potential anti-Plasmodium drug target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.