ArticleAmerican journal of respiratory and critical care medicine2019
Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma.
Article in American journal of respiratory and critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Acute and chronic exposure to air pollution in relation with incidence, prevalence, severity and mortality of COVID-19: a rapid systematic review.Environmental health : a global access science source · 2021Pooled it
- The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness.The Journal of clinical investigation · 2021Trial
- Repeated air pollution exposure predisposes to adverse outcomes from acute lung injury.Particle and fibre toxicology · 2026Article
- Impact of air pollution on exacerbations of respiratory and cardiovascular diseases for the intensivist: a narrative review.Intensive care medicine experimental · 2026Review
- Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Medical sciences (Basel, Switzerland) · 2026Review
- 1-Nitropyrene induces acute lung injury via SYVN1/Caspase-11-mediated apoptosis and pyroptosis in pulmonary epithelial cells.Frontiers in pharmacology · 2026Article
- Chronic Ozone Exposure and Its Role in the Development of Age-Related Cataracts: A Comprehensive Analysis.Environment & health (Washington, D.C.) · 2025Article
- Particulate matter air pollution: effects on the respiratory system.The Journal of clinical investigation · 2025Review
- The GenusLife (Basel, Switzerland) · 2025Review
- Factors impacting sleep center no-show rates after hospital discharge using geospatial coding in Appalachia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Advances in acute respiratory distress syndrome: focusing on heterogeneity, pathophysiology, and therapeutic strategies.Signal transduction and targeted therapy · 2025Review
- Article
- Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Observational
- Environmental Risk Factors for Acute Respiratory Distress Syndrome.Clinics in chest medicine · 2024Review
- The Relevance of the Endothelium in Cardiopulmonary Disorders.International journal of molecular sciences · 2024Review
- Effects of ozone exposure on lung injury, inflammation, and oxidative stress in a murine model of nonpneumonic endotoxemia.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Molecular markers of type II alveolar epithelial cells in acute lung injury by bioinformatics analysis.Scientific reports · 2023Article
- Effects of ambient air pollutants on ARDS incidence and outcome: a narrative review.Annals of intensive care · 2023Review
- Exposure to ambient air pollutants and acute respiratory distress syndrome risk in sepsis.Intensive care medicine · 2023Article
- Medical Industry Contributions to the Climate Crisis: Behind the Green Drapes.Canadian journal of respiratory, critical care, and sleep medicine · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
rationaleExposure to air pollution has molecular and physiologic effects on the lung that may increase the risk of acute respiratory distress syndrome (ARDS) after injury.
objectivesTo determine the association of short- and long-term air pollutant exposures and ARDS risk after severe trauma.
methodsWe analyzed data from a prospective cohort of 996 critically ill patients presenting with acute trauma and an injury severity score greater than 15. Exposures to ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide, and particulate matter less than 2.5 μm were assessed by weighted averages of daily levels from all monitors within 50 km of the geocoded location of a patient's residence. Patients were followed for 6 days for the development of ARDS according to Berlin Criteria. The association between each exposure and ARDS was determined via multivariable logistic regression adjusting for potential confounders. MEASUREMENTS AND MAIN
resultsARDS developed in 243 (24%) patients. None of the short-term exposures averaged over the 3 days before presentation was associated with ARDS, except sulfur dioxide, which demonstrated a nonlinear association. Nitrogen dioxide, sulfur dioxide, and particulate matter less than or equal to 2.5 μm in aerodynamic diameter exposure over the 6 weeks before presentation was significantly associated with ARDS (P < 0.05). All long-term exposures (3 yr) were associated with ARDS (P < 0.01) in adjusted models, despite exposure levels largely below U.S. and European Union air quality standards.
conclusionsLong-term low- to moderate-level air pollutant exposure is associated with a greater risk of developing ARDS after severe trauma and represents a novel and potentially modifiable environmental risk factor for ARDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.