Evidence map›Paper›PMID 30067380›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

TRPC1 intensifies house dust mite-induced airway remodeling by facilitating epithelial-to-mesenchymal transition and STAT3/NF-κB signaling.

Qinqin Pu, Yuanyu Zhao, Yuyang Sun, Ting Huang, Ping Lin, Chuanmin Zhou, Shugang Qin, Brij B Singh, Min Wu

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Update on HDM Allergy: Principal Changes over the Years.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Inhalation of nebulizedAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020
    Article
  14. Article
  15. Store-Operated CaInternational journal of molecular sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Qinqin PuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Yuanyu ZhaoDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Yuyang SunDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Ting HuangDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Ping LinDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Chuanmin ZhouDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Shugang QinDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Brij B SinghDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
Min WuDepartment of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, North Dakota, USA; and.
University of North Dakota · USThe University of Texas Health Science Center at San Antonio · USState Key Laboratory of Biotherapy

Funding

Research CoresP20GM103442 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI Donald A. Sens · 2012 to 2026
$53.0M
Yersina perstis interactions with macrophagesP20GM113123 · NIGMS · UNIVERSITY OF NORTH DAKOTA · PI COMBS, COLIN K · 2016 to 2025
$19.9M
TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
Epigenetic regulations in Sjogern's syndromeR01DE022765 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2017 to 2021
$1.8M
Lung innate immunity against bacterial infectionR01AI109317 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI WU, MIN · 2014 to 2018
$1.7M
Lung epithelium collaborates with alveolar macrophages in host defenseR15AI101973 · NIAID · UNIVERSITY OF NORTH DAKOTA · PI WU, MIN · 2012 to 2012
$414k
NIAID NIH HHS R01 AI109317NIAID NIH HHS R15 AI101973NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R01 DE022765NIGMS NIH HHS P20 GM103442NIGMS NIH HHS P20 GM113123
6 · The paper itself

Abstract

Airway remodeling with progressive epithelial alterations in the respiratory tract is a severe consequence of asthma. Although dysfunctional signaling transduction is attributed to airway inflammation, the exact mechanism of airway remodeling remains largely unknown. TRPC1, a member of the transient receptor potential canonical Ca

Indexed as

PyroglyphidaeSignal TransductionAirway RemodelingAnimalsBronchiCalciumCollagenDisease Models, AnimalDown-RegulationEpithelial CellsEpithelial-Mesenchymal TransitionHypersensitivityInflammationIon TransportMiceMice, KnockoutCalciumCollagenNF-kappa BStat3 protein, mouseSTAT3 Transcription Factortransient receptor potential cation channel, subfamily C, member 1TRPC Cation Channelsasthmacell signalingion channeltranscription factors

Identifiers

PMID30067380
PMCPMC6355092
OpenAlexW2885140957

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.