Evidence map›Paper›PMID 30067305›Full record

ArticleChembiochem : a European journal of chemical biology2018

The General Explanation Method with NMR Spectroscopy Enables the Identification of Metabolite Profiles Specific for Normal and Tumor Cell Lines.

Klemen Pečnik, Vesna Todorović, Maša Bošnjak, Maja Čemažar, Igor Kononenko, Gregor Serša, Janez Plavec

Open access · hybridAbstract readComparative Study
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. The application of artificial neural networks in metabolomics: a historical perspective.Metabolomics : Official journal of the Metabolomic Society · 2019
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Klemen PečnikSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000, Ljubljana, Slovenia.
Vesna TodorovićInstitute of Oncology, Zaloška cesta 2, 1000, Ljubljana, Slovenia.
Maša BošnjakInstitute of Oncology, Zaloška cesta 2, 1000, Ljubljana, Slovenia.
Maja ČemažarInstitute of Oncology, Zaloška cesta 2, 1000, Ljubljana, Slovenia.
Igor KononenkoFaculty of Computer and Information Science, University of Ljubljana, Večna pot 113, 1001, Ljubljana, Slovenia.
Gregor SeršaInstitute of Oncology, Zaloška cesta 2, 1000, Ljubljana, Slovenia.
Janez PlavecSlovenian NMR Centre, National Institute of Chemistry, Hajdrihova 19, SI-1000, Ljubljana, Slovenia.ORCID 0000-0003-1570-8602
Institute of Oncology Ljubljana · SIUniversity of Ljubljana · SINational Institute of Chemistry · SI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Machine learning models in metabolomics, despite their great prediction accuracy, are still not widely adopted owing to the lack of an efficient explanation for their predictions. In this study, we propose the use of the general explanation method to explain the predictions of a machine learning model to gain detailed insight into metabolic differences between biological systems. The method was tested on a dataset of

Indexed as

MetabolomeCell LineDatasets as TopicHumansLungLung NeoplasmsMachine LearningMagnetic Resonance SpectroscopyMetabolomicscancergeneral explanation methodmachine learningmetabolomicsNMR spectroscopy

Identifiers

PMID30067305
PMCPMC6220813
OpenAlexW2885650252

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.