ArticleAngewandte Chemie (International ed. in English)2018
Metallaphotoredox Difluoromethylation of Aryl Bromides.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 188 citations in OpenAlex.
- Electron-Donor-Acceptor Enabled Electrophilic C(spJACS Au · 2026Article
- Electrosynthesis of 1,1-Bis(difluoromethyl)alkenes via Twofold C-H Difluoromethylation as Bioisosteres of Elusive 1,1-Enediols.Nature communications · 2026Article
- Photochemical Fluoroalkylations with Fluorinated Gases Facilitated by a Robust Metal-Organic Framework.Journal of the American Chemical Society · 2026Article
- Dual transition metal electrocatalysis for difluoromethylation of Aryl halides using potassium difluoroacetate.Nature communications · 2025Article
- Synthetic Strategies to Access Fluorinated Azoles.European journal of organic chemistry · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Highly Enantioselective Decarboxylative Difluoromethylation.Journal of the American Chemical Society · 2024Article
- Direct Synthesis of 2-Hydroxytrifluoroethylacetophenones via Organophotoredox-Mediated Net-Neutral Radical/Polar Crossover.The Journal of organic chemistry · 2024Article
- Sulfone Electrophiles in Cross-Electrophile Coupling: Nickel-Catalyzed Difluoromethylation of Aryl Bromides.ACS catalysis · 2024Article
- Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch.Nature communications · 2024Article
- Synergistic Merger of Ketone, Halogen Atom Transfer (XAT), and Nickel-Mediated C(spACS organic & inorganic Au · 2024Article
- Photocatalytic Multicomponent Annulation of Amide-Anchored 1,7-Diynes Enabled by Deconstruction of Bromotrichloromethane.Molecules (Basel, Switzerland) · 2024Article
- Photoinduced radical tandem annulation of 1,7-diynes: an approach for divergent assembly of functionalized quinolin-2(1H)-ones.Frontiers in chemistry · 2024Article
- Photocatalytic fluoroalkylation by ligand-to-metal charge transfer.Frontiers in chemistry · 2024Review
- Difluoroalkylation of Anilines via Photoinduced Methods.The Journal of organic chemistry · 2023Article
- Efficient Synthesis of 1Molecules (Basel, Switzerland) · 2023Article
- Zinc-Free, Scalable Reductive Cross-Electrophile Coupling Driven by Electrochemistry in an Undivided Cell.ACS catalysis · 2022Article
- The Merger of Benzophenone HAT Photocatalysis and Silyl Radical-Induced XAT Enables Both Nickel-Catalyzed Cross-Electrophile Coupling and 1,2-Dicarbofunctionalization of Olefins.ACS catalysis · 2022Article
- Investigations into mechanism and origin of regioselectivity in the metallaphotoredox-catalyzed α-arylation ofChemical science · 2022Article
- Kinetics of a Ni/Ir-Photocatalyzed Coupling of ArBr with RBr: Intermediacy of ArNiJournal of the American Chemical Society · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Herein, we report a convenient and broadly applicable strategy for the difluoromethylation of aryl bromides by metallaphotoredox catalysis. Bromodifluoromethane, a simple and commercially available alkyl halide, is harnessed as an effective source of difluoromethyl radical by silyl-radical-mediated halogen abstraction. The merger of this fluoroalkyl electrophile activation pathway with a dual nickel/photoredox catalytic platform enables the difluoromethylation of a diverse array of aryl and heteroaryl bromides under mild conditions. The utility of this procedure is showcased in the late-stage functionalization of several drug analogues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.