ArticleMolecular medicine reports2018
Role of miR‑449b‑3p in endometriosis via effects on endometrial stromal cell proliferation and angiogenesis.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Liquid Biopsy in Endometriosis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Dysregulation of Key Biological Processes in Endometriosis Pathophysiology.Current molecular medicine · 2026Review
- Treponema pallidum inhibits CD4+ T-cell proliferation through METAP2: insights from Mendelian randomization analysis.AMB Express · 2025Article
- Decreased expression ofInternational journal of reproductive biomedicine · 2024Article
- Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis.Life (Basel, Switzerland) · 2022Review
- Genetic association between miR-27a and miR-449b polymorphisms and susceptibility to diabetes mellitus.Biomedical reports · 2022Article
- Role of repressed microRNAs in endometriosis.Medical molecular morphology · 2022Review
- hsa-miR-199a-3p Inhibits Motility, Invasiveness, and Contractility of Ovarian Endometriotic Stromal Cells.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature).International journal of molecular sciences · 2021Review
- Identification of a MicroRNA Signature Associated With Lymph Node Metastasis in Endometrial Endometrioid Cancer.Frontiers in genetics · 2021Article
- The Genetic Background of Endometriosis: Can ESR2 and CYP19A1 Genes Be a Potential Risk Factor for Its Development?International journal of molecular sciences · 2020Review
- Article
- Role of Non-coding RNAs in the Pathogenesis of Endometriosis.Frontiers in oncology · 2020Review
- Serum Exosomal MicroRNAs as Potential Circulating Biomarkers for Endometriosis.Disease markers · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endometriosis is a common gynecological disease and the pathogenesis is not clearly understood. Previous studies have demonstrated via microarray techniques that microRNA (miR)‑449b was significantly downregulated both in ectopic and eutopic endometrium in patients with endometriosis. In the present study, the aberrant expression of miR‑449b was further confirmed by reverse transcription‑quantitative polymerase chain reaction. It was demonstrated that miR‑449b‑3p was downregulated in ectopic and eutopic tissues from women with endometriosis, and the same expression pattern was observed in endometrial stromal cells (ESCs) of eutopic endometrium from women with endometriosis and normal endometrium from women without endometriosis. Functional analysis, including an MTT assay, apoptosis conducted by flow cytometry, capillary‑like tube formation assay and invasion assay, indicated that the upregulated expression of miR‑449b‑3p inhibited the proliferation of ESCs and that the supernatants of miR‑449b‑overexpressing ESCs inhibited the formation of tubular structures in human umbilical vein endothelial cells, whereas it has no effect on ESC apoptosis and invasiveness. These results suggest that the aberrant expression of miR‑449b‑3p was involved in the development and progression of endometriosis.
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Registered trials
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