Evidence map›Paper›PMID 30066917›Full record

ArticleOncology reports2018

Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer.

Xuanmin Chen, Defeng Li, Nannan Wang, Meifeng Yang, Aijun Liao, Shuling Wang, Guangsheng Hu, Bing Zeng, Yuhong Yao, Diqun Liu and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Xuanmin ChenDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Defeng LiDepartment of Gastroenterology, The 2nd Clinical Μedicine College (Shenzhen People's Hospital) of Jinan University, Shenzhen, Guangdong 518020, P.R. China.
Nannan WangDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Meifeng YangDepartment of Hematology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Aijun LiaoDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Shuling WangDepartment of Gastroenterology, Shanghai Hospital, Second Military Medical University, Shanghai 200433.
Guangsheng HuDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Bing ZengDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Yuhong YaoDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Diqun LiuDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Han LiuDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Weiwei ZhouDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Weisheng XiaoDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Peiyuan LiDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Chen MingDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Song PingDepartment of Hematology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Pingfang ChenDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Li JingDepartment of Gastroenterology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, P.R. China.
Yu BaiDepartment of Gastroenterology, Shanghai Hospital, Second Military Medical University, Shanghai 200433.
Jun YaoDepartment of Gastroenterology, The 2nd Clinical Μedicine College (Shenzhen People's Hospital) of Jinan University, Shenzhen, Guangdong 518020, P.R. China.
First Affiliated Hospital of University of South China · CNUniversity of South China · CNJinan University · CNSecond Military Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is one of the most common malignancies that threatens human health. As the molecular mechanisms unerlying GC are not completely understood, identification of genes related to GC could provide new insights into gene function as well as potential treatment targets. We discovered that UGT2B15 may contribute to the pathogenesis and progression of GC using GEO data and bioinformatic analysis. Using TCGA data, UGT2B15 mRNA was found to be significantly overexpressed in GC tissues; patients with higher UGT2B15 had a poorer prognosis. It was further discovered that UGT2B15 and FOXA1 were both upregulated, and UGT2B15 and Foxa1 were positively correlated in GC. It is known that Foxa1 is a vital threshold to activate the Hippo‑YAP signaling pathway. In addition, we suggest that a potential molecular mechanisms includes UGT2B15 which may upregulate Foxa1, activate the Hippo‑YAP signaling pathway and contribute to the development of GC. Taken together, our findings demonstrate that UGT2B15 may be an oncogene in GC and is a promising therapeutic target for cancer treatment.

Indexed as

Adaptor Proteins, Signal TransducingApoptosisBiomarkers, TumorCase-Control StudiesCell ProliferationComputational BiologyFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticGlucuronosyltransferaseHepatocyte Nuclear Factor 3-alphaHippo Signaling PathwayHumansMaleMiddle AgedPhosphoproteinsAdaptor Proteins, Signal TransducingBiomarkers, TumorFOXA1 protein, humanGlucuronosyltransferaseHepatocyte Nuclear Factor 3-alphaPhosphoproteinsProtein Serine-Threonine KinasesTranscription FactorsUDP-glucuronosyltransferase 2B15, humanYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID30066917
PMCPMC6111708
OpenAlexW2884763448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.