ArticleRevista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo
ADRENAL CARCINOMA IN CHILDREN: LONGITUDINAL STUDY IN MINAS GERAIS, BRAZIL.
Article in Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 11 citations in OpenAlex.
- Epidemiological trends of adrenalectomies in Brazil: A cohort-based study of the Brazilian public health system.Archives of endocrinology and metabolism · 2025Article
- LowCancers · 2024Article
- Adrenocortical carcinoma in a 10-month-old infant: A literature review and a rare case report.Annals of medicine and surgery (2012) · 2023Article
- Review
- Photographic Journey of Cushing Syndrome.Indian journal of pediatrics · 2021Article
- ADRENAL CORTICAL CARCINOMA IN INFANCY.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloArticle
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4 authors at 1 institution in 1 country.
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Abstract
objectiveTo analyze clinical, laboratory and histopathological features and the path to diagnosis establishment and treatment of patients with adrenal carcinoma (AC).
methodsRetrospective study with 13 patients assisted at the pediatric oncology service of Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil, between 2004 and 2015.
resultsAge at diagnosis ranged from 1.0 to 14.8 years (median: 2.0 years). Manifestations of hypercortisolism were identified in all cases and virilization in all girls. All patients met the Weiss criteria to AC histopathological diagnosis. Immunohistochemistry was performed in 61.5% of the cases. Most patients had stage I disease (76.9%). All subjects were submitted to total tumor resection. Two patients (stages III and IV disease) received chemotherapy associated to mitotane. The only death case was that of a patient with stage IV disease. The probability of overall survival for the entire group up to 5.0 years was 92.3±7.4%. The median time between the onset of symptoms and diagnosis was 9.5 months, and 6.0 months between first visit and start of treatment.
conclusionsLow age at diagnosis, predominance of cases with localized disease and complete tumor resection - with only one case of tumor capsule rupture - can possibly explain the favorable evolution of the studied population. The long period between onset of symptoms and diagnosis highlights the importance of training pediatricians for early recognition of AC signs and symptoms.
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