Evidence map›Paper›PMID 30066439›Full record

ArticleBJU international2019

Cost-effectiveness of surveillance schedules in older adults with non-muscle-invasive bladder cancer.

Eveline A M Heijnsdijk, Daan Nieboer, Tullika Garg, Iris Lansdorp-Vogelaar, Harry J de Koning, Matthew E Nielsen

Open access · hybridAbstract read
In one paragraph

Article in BJU international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Economic Impact of Bladder Cancer in the USA.PharmacoEconomics - open · 2024
    Article
  5. Article
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Eveline A M HeijnsdijkDepartment of Public Health, The Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-4890-6069
Daan NieboerDepartment of Public Health, The Erasmus University Medical Center, Rotterdam, The Netherlands.
Tullika GargDepartments of Urology, Epidemiology and Health Services Research, Geisinger, Danville, PA, USA.
Iris Lansdorp-VogelaarDepartment of Public Health, The Erasmus University Medical Center, Rotterdam, The Netherlands.
Harry J de KoningDepartment of Public Health, The Erasmus University Medical Center, Rotterdam, The Netherlands.
Matthew E NielsenDepartments of Urology, Epidemiology and Health Policy and Management, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.
Erasmus MC · NLGeisinger Health System · USUniversity of North Carolina Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo estimate the cost-effectiveness of surveillance schedules for non-muscle-invasive bladder cancer (NMIBC) amongst older adults. PATIENTS AND

methodsWe developed a MIcrosimulation SCreening ANalysis (MISCAN) microsimulation model to compare the cost-effectiveness of various surveillance schedules (every 3 months to every 24 months, for 2, 5 or 10 years or lifetime) for older adults (aged 65-85 years) with NMIBC. For each surveillance schedule we calculated total costs per patient and the number of quality adjusted life-years (QALYs) gained. Incremental cost-effectiveness ratios (ICERs), as incremental costs per QALY gained, were calculated using a 3% discount.

resultsAs age increased, the number of QALYs gained per patient decreased substantially. Surveillance of patients aged 65 years resulted in 2-7 QALYs gained, whereas surveillance at age 85 years led to <1 QALY gained. The total costs of the surveillance schedules also decreased as age increased. The ICER of 6-monthly surveillance at age 65 years for lifetime was $4999 (American dollars)/QALY gained. Amongst patients aged >75 years, the incremental yield of QALY gains for any increase in surveillance frequency and/or duration was quite modest (<2 QALYs gained).

conclusionWith increasing age, surveillance for recurrences leads to substantially fewer QALYs gained. These data support age-specific surveillance recommendations for patients treated for NMIBC.

Indexed as

Health Care CostsPopulation SurveillanceAgedAged, 80 and overComputer SimulationCost-Benefit AnalysisHumansMuscle, SmoothNeoplasm InvasivenessNeoplasm Recurrence, LocalQuality-Adjusted Life YearsTime FactorsUrinary Bladder Neoplasmsbladder cancercost-effectivenesssurveillance

Identifiers

PMID30066439
PMCPMC6378589
OpenAlexW2886978124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.