ArticleEuropean journal of nutrition2019
Metabolic targets of watercress and PEITC in MCF-7 and MCF-10A cells explain differential sensitisation responses to ionising radiation.
Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Watercress (Life (Basel, Switzerland) · 2025Review
- Evaluating the Anti-Oxidant and Anti-Inflammatory Properties of Watercress Supplementation at Short-Term Follow-Up: A Systematic Review of Randomized Controlled Trials.Food science & nutrition · 2025Review
- Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via ItsAntioxidants (Basel, Switzerland) · 2024Article
- Article
- Article
- Further evidence to support acute and chronic anti-inflammatory effects ofResearch in pharmaceutical sciences · 2022Article
- Phenylethyl Isothiocyanate: A Bioactive Agent for Gastrointestinal Health.Molecules (Basel, Switzerland) · 2022Review
- Phenethyl Isothiocyanate-Containing Carbomer Gel for Use against Squamous Cell Carcinoma.Pharmaceutics · 2021Article
- Chitosan-olive oil microparticles for phenylethyl isothiocyanate delivery: Optimal formulation.PloS one · 2021Article
- A Narrative Review on Therapeutic Potentials ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
- Phenylethyl Isothiocyanate Extracted from Watercress By-Products with Aqueous Micellar Systems: Development and Optimisation.Antioxidants (Basel, Switzerland) · 2020Article
- Article
- Thanatometabolomics: introducing NMR-based metabolomics to identify metabolic biomarkers of the time of death.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Radiation-induced alterations in the cancer microenvironment (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
purposeWatercress is a rich source of phytochemicals with anticancer potential, including phenethyl isothiocyanate (PEITC). We examined the potential for watercress extracts and PEITC to increase the DNA damage caused by ionising radiation (IR) in breast cancer cells and to be protective against radiation-induced collateral damage in healthy breast cells. The metabolic events that mediate such responses were explored using metabolic profiling.
methods
resultsBoth the watercress extract and PEITC-modulated biosynthetic pathways of lipid and protein synthesis and resulted in changes in cellular bioenergetics. Disruptions to the redox balance occurred with both treatments in the two cell lines, characterised by shifts in the abundance of glutathione. PEITC enhanced the sensitivity of the breast cancer cells to IR increasing the effectiveness of the cancer-killing process. In contrast, watercress-protected non-tumorigenic breast cells from radiation-induced damage. These effects were driven by changes in the cellular content of the antioxidant glutathione following exposure to PEITC and other phytochemicals in watercress.
conclusionThese findings support the potential prophylactic impact of watercress during radiotherapy. Extracted compounds from watercress and PEITC differentially modulate cellular metabolism collectively enhancing the therapeutic outcomes of radiotherapy.
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