ReviewCurrent infectious disease reports2018
Substance Use and Adherence to Antiretroviral Therapy: What Is Known and What Is Unknown.
Review in Current infectious disease reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Strategies to Improve PrEP Adherence in People Who Use Drugs: A Systematic Review.AIDS and behavior · 2026Pooled it
- Differential Effects of Substance Use on HIV Care and Symptom Outcomes: A Longitudinal Analysis Among People with HIV.AIDS patient care and STDs · 2025Trial
- Trial
- Association Between Housing Instability and HIV Care Outcomes Among People With HIV in the United States.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- Neighborhood Resources Indirectly Linked to HIV Medication Adherence Through Social Determinants of Health Among Digitally Surveyed Partnered Men Who Have Sex with Men.AIDS and behavior · 2026Article
- Changes in Stimulant Use Over Time Among Men Who Have Sex with Men in Philadelphia, Baltimore, and Washington, DC, 2008-2023.AIDS and behavior · 2026Article
- Factors Associated with ART Adherence and Sustained Viral Suppression Among US Young Adults with HIV, 2015-2022.AIDS and behavior · 2026Article
- Alcohol Use Disorder Diagnoses and HIV Preexposure Prophylaxis Adherence and Continuation: a Retrospective Cohort Study.Journal of general internal medicine · 2026Article
- Comparison of Self-Reported Substance Use with Outcomes of Urine Testing among Men Who Have Sex with Men in Africa Participating in HPTN 075.AIDS and behavior · 2025Observational
- Real-World Persistence in Adults with HIV and Mental Health or Substance Use Disorders After Restarting Antiretroviral Therapy in the United States.Advances in therapy · 2025Observational
- Barriers and facilitators to implementing electronic patient reported outcome screening for mental illness and substance use disorders at HIV clinics in Alabama: a qualitative study.BMC health services research · 2025Article
- Pilot of Methadone for Recently Incarcerated People with Human Immunodeficiency Virus and Opioid Use in South Africa.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2025Article
- Cognitive behavioral therapy for antiretroviral therapy adherence and treatment outcomes among people living with HIV: a systematic review and meta-analysis.Nature. Mental health · 2025Article
- Cannabis use is associated with a lower likelihood of presence of HIV drug resistance mutations in a retrospective cohort of adults with HIV.NeuroImmune pharmacology and therapeutics · 2025Article
- Severity and Number of Substances Used are Independently Associated with Antiretroviral Therapy Adherence Over Time among People with HIV in the Current Treatment Era.AIDS and behavior · 2025Article
- Article
- mHealth Engagement for Antiretroviral Medication Adherence Among People With HIV and Substance Use Disorders: Observational Study.Journal of medical Internet research · 2024Observational
- HIV status and substance use disorder treatment need and utilization among adults in the United States, 2015-2019: Implications for healthcare service provision and integration.Journal of substance use and addiction treatment · 2024Article
- On the issue of treating HIV in people with syndemic mental-health and substance-use disorders.Nature. Mental health · 2024Article
- Alcohol and drug use severity are independently associated with antiretroviral adherence in the current treatment era.AIDS care · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewPeople who use drugs face multiple challenges to achieve optimal HIV treatment outcomes. This review discusses the current knowledge in substance use and antiretroviral therapy adherence, highlighting recent findings and potential interventions. RECENT
findingsStudies continue to demonstrate the negative impacts of substance use and related disorders on antiretroviral therapy adherence, with the exception of cannabis. Evidence-based addiction treatment, in particular, opioid agonist therapy, appears to improve adherence levels. Most individual-level adherence specific interventions did not provide sustained effects, and no studies evaluating structural-level interventions were found. Findings suggest the urgent need to scale-up opioid agonist therapy, as well as to simultaneously address multiple structural barriers to care to optimize HIV treatment outcomes among people who use drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.