Evidence map›Paper›PMID 30066053›Full record

ArticleEJNMMI research2018

Quantification of O-(2-[

Thomas Koopman, Niels Verburg, Robert C Schuit, Petra J W Pouwels, Pieter Wesseling, Albert D Windhorst, Otto S Hoekstra, Philip C de Witt Hamer, Adriaan A Lammertsma, Ronald Boellaard and 1 more

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. The confounding effects of microvascular physiology on the uptake and diagnostic accuracy of [European journal of nuclear medicine and molecular imaging · 2026
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  5. Glioblastoma PET/MRI: kinetic investigation of [European journal of nuclear medicine and molecular imaging · 2023
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  8. Nuclear Medicine Imaging Procedures in Oncology.Methods in molecular biology (Clifton, N.J.) · 2021
    Article
  9. Quantitative parametric maps of O-(2-[Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Article
  10. Article
  11. Direct comparison of [EJNMMI research · 2019
    Article
  12. 4-Borono-2-Annals of nuclear medicine · 2019
    Review
  13. Voxel-wise analysis of dynamicEJNMMI research · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Thomas KoopmanDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands. t.koopman@vumc.nl.ORCID http://orcid.org/0000-0003-3123-5278
Niels VerburgNeurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Robert C SchuitDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Petra J W PouwelsDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Pieter WesselingDepartment of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
Albert D WindhorstDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Otto S HoekstraDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Philip C de Witt HamerNeurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Adriaan A LammertsmaDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Ronald BoellaardDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Maqsood YaqubDepartment of Radiology and Nuclear Medicine, VU University Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
Amsterdam UMC Location Vrije Universiteit Amsterdam · NLUniversity Medical Center Groningen · NLUniversity Medical Center Utrecht · NL

Funding

Cancer Center Amsterdam (NL) CCA2012-2-05KWF Kankerbestrijding OAA/H1/VU 2015-7502ZonMw 10-10400-98-14002
6 · The paper itself

Abstract

backgroundThis study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[

resultsThe optimal tracer kinetic model was the reversible two-tissue compartment model. Agreement analysis of binding potential estimates derived from reference tissue input models with the distribution volume ratio (DVR)-1 derived from the plasma input model showed no significant average difference and limits of agreement of - 0.39 and 0.37. Given the range of DVR-1 (- 0.25 to 1.5), these limits are wide. For the simplified methods, the 60-90 min tumour-to-blood ratio to parent plasma concentration yielded the highest correlation with volume of distribution V

conclusionUptake of [

Indexed as

FETKinetic modellingQuantificationSUVSUVR

Identifiers

PMID30066053
PMCPMC6068050
OpenAlexW2887445161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.