Evidence map›Paper›PMID 30065940›Full record

ArticleBioMed research international2018

Blockade of RBP-J-Mediated Notch Signaling Pathway Exacerbates Cardiac Remodeling after Infarction by Increasing Apoptosis in Mice.

Yanru He, Si Pang, Jia Huang, Kongbo Zhu, Jiayi Tong, Yaoliang Tang, Genshan Ma, Lijuan Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. New Insights into the Reparative Angiogenesis after Myocardial Infarction.International journal of molecular sciences · 2023
    Review
  7. Unlocking cardiomyocyte renewal potential for myocardial regeneration therapy.Journal of molecular and cellular cardiology · 2023
    Review
  8. Review
  9. Signaling pathways and targeted therapy for myocardial infarction.Signal transduction and targeted therapy · 2022
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. OncoTargets and therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yanru HeDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.ORCID 0000-0002-6801-9088
Si PangDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.
Jia HuangDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.
Kongbo ZhuDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.
Jiayi TongDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.
Yaoliang TangDepartment of Cardiovascular Medicine, Georgia Regents University, USA.ORCID 0000-0002-8372-1545
Genshan MaDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.ORCID 0000-0003-4332-3013
Lijuan ChenDepartment of Cardiology, Zhongda Hospital Affiliated to Southeast University, Nanjing, China.ORCID 0000-0002-5754-9139
Zhongda Hospital Southeast University · CNAugusta University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIschemic heart disease (IHD) is the major cause of death in patients with cardiovascular disease. Cardiac remodeling is a common pathological change following myocardial infarction (MI), and cardiomyocyte apoptosis plays a key role in this change. Transcription factor recombination signal-binding protein-J (RBP-J)-mediated Notch signaling pathway has been implicated in several inherited cardiovascular diseases, including aortic valve diseases, but whether the RBP-J-mediated Notch signaling pathway plays a role in cardiomyocyte apoptosis after MI is unclear.

methodWe crossed RBP-J

resultsRBP-J knockout decreased the survival rate and deteriorated post-MI remodeling and function in mice, and this effect was associated with increased cardiomyocyte apoptosis. The potential mechanisms might be related to the downregulated expression of bcl-2, upregulated expression of bax, and cleaved-caspase 3 to exacerbate cardiomyocyte apoptosis.

conclusionThese findings show that the RBP-J-mediated Notch signaling pathway in cardiomyocytes limits ventricular remodeling and improves cardiac function after MI. The RBP-J-mediated Notch signaling pathway has a protective role in cardiomyocyte apoptosis following cardiac injury.

Indexed as

ApoptosisAnimalsHumansImmunoglobulin J Recombination Signal Sequence-Binding ProteinMiceMice, KnockoutMice, TransgenicMyocardial InfarctionMyocytes, CardiacReceptors, NotchSignal TransductionVentricular RemodelingImmunoglobulin J Recombination Signal Sequence-Binding ProteinRbpj protein, mouseReceptors, Notch

Identifiers

PMID30065940
PMCPMC6051300
OpenAlexW2810602447

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.