ArticleHereditary cancer in clinical practice2018
CD36 - a plausible modifier of disease phenotype in familial adenomatous polyposis.
Article in Hereditary cancer in clinical practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- CD36 rs1761667 Polymorphism and Its Impact on Molecular Signatures in Bladder Cancer.Diseases (Basel, Switzerland) · 2026Article
- CD36 polymorphisms and the age of disease onset in patients with pathogenic variants within the mutation cluster region of APC.Hereditary cancer in clinical practice · 2021Article
- Advances in Identification of Susceptibility Gene Defects of Hereditary Colorectal Cancer.Journal of Cancer · 2019Review
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFamilial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum. Animal models have consistently suggested the role of modifier genes in determining disease phenotype, yet none have been substantiated in the human population. The mouse homologue of
methodsThree single nucleotide polymorphisms (SNPs); rs1049673, rs1761667 and rs1984112 in
resultsThe results revealed a substantially lower age of polyposis diagnosis for patients belonging to the severe FAP group (harbouring
conclusionsThis study provides evidence for patients belonging to the MCR and AFAP groups harbouring specific genotypes for SNPs in
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