ArticleOncology letters2018
Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors.
Article in Oncology letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Epidemiologic Trends and Factors Associated With Overall Survival for Patients With Hepatobiliary Neuroendocrine Neoplasms in the United States.Cancer reports (Hoboken, N.J.) · 2025Article
- DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms.Nature communications · 2025Article
- Primary hepatic neuroendocrine tumor with a suspicious pulmonary nodule: A case report and literature review.World journal of clinical oncology · 2025Article
- Curative resection of multiple primary neuroendocrine tumors enabled by preoperative imaging: a case report.Journal of surgical case reports · 2025Article
- Primary hepatic neuroendocrine neoplasms: imaging characteristics and misdiagnosis analysis.Frontiers in oncology · 2024Article
- A case of neuroendocrine carcinoma with massive invasion to the liver and multiorgan causing acute liver failure.Clinical journal of gastroenterology · 2023Article
- Primary hepatic neuroendocrine neoplasm presenting as a massive cystic liver tumor mimicking mucinous cystic neoplasm of the liver: A case report and literature review.Oncology letters · 2023Article
- Predicting the survival probability of functional neuroendocrine tumors treated with peptide receptor radionuclide therapy: Serbian experience.Frontiers in endocrinology · 2023Article
- A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients.Frontiers in medicine · 2023Article
- Primary Hepatic Neuroendocrine Carcinoma with Thrombocytopenia Due to Diffuse Bone Marrow and Splenic Infiltration: An Autopsy Case.Internal medicine (Tokyo, Japan) · 2022Article
- Hepatectomy and pneumectomy combined with targeted therapy for primary hepatic neuroendocrine carcinoma: Case report and review of the literature.Frontiers in surgery · 2022Article
- Primary hepatic neuroendocrine carcinoma diagnosed by needle biopsy: a case report.Surgical case reports · 2021Article
- Neuroendocrine neoplasms of the biliary tree, liver and pancreas: a pathological approach.Pathologica · 2021Review
- Efficacy of Chemotherapy versus Transcatheter Arterial Chemoembolization in Patients with Advanced Primary Hepatic Neuroendocrine Carcinoma and an Analysis of the Prognostic Factors: A Retrospective Study.Cancer management and research · 2021Article
- A case of primary hepatic mixed neuroendocrine-non-neuroendocrine tumor (MiNEN) associated with gallbladder carcinosarcoma.Clinical journal of gastroenterology · 2020Article
- Primary hepatic neuroendocrine tumour masquerading as a giant haemangioma: an unusual presentation of a rare disease.BMJ case reports · 2020Article
- Clinicopathological Characteristics and Survival Outcomes of Primary Hepatic Neuroendocrine Tumor: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Primary hepatic neuroendocrine carcinoma coexisting with distal cholangiocarcinoma: A case report and review of the literature.Medicine · 2020Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroendocrine tumors (NETs) of the gastrointestinal tract often spread to the liver, while primary hepatic NETs (PHNETs), first described by Edmondson in 1958, are very rare. The majority of existing reports regarding PHNETs have small sample sizes, and the clinicopathological characteristics and prognostic factors are still unclear. The aim of the present study was to analyze the clinicopathological features and explore the prognostic factors of PHNETs. From March 2012 to March 2017, 28 cases of PHNETs were retrospectively evaluated to analyze the clinicopathological features and explore the prognostic factors of PHNETs. The 28 PHNETs patients were males (n=15) and females (n=13) aged between 32 and 76 years (mean=53 years). Among them, 16 patients had clinical symptoms. The remaining 12 patients had no obvious clinical symptoms, only hepatoncus was observed during physical examination. Single-factor analysis showed that carbohydrate antigen 125 (CA125), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hemoglobin (HB), Ki-67 positive index (PI), surgical treatment and pathological grading were correlated to PHNET prognosis (P<0.05); multifactor analysis revealed that Ki-67 PI was associated with the prognosis (P<0.05). Thus, the prognosis of PHNETs may be effectively predicted using the indexes of CA125, ALT, AST, HB, Ki-67 PI, pathological grading and surgical treatment. Pathological classification of grade 3, high expression of Ki-67 PI, abnormal elevation of CA125, abnormalities of ALT and AST, anemia and lack of radical operation indicated a poor prognosis. High expression of Ki-67 PI was an independent prognostic factor for PHNETs.
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