ArticleResearch in pharmaceutical sciences2018
The effect of metformin on morphine analgesic tolerance and dependence in rats.
Article in Research in pharmaceutical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Metformin use and outcomes after arthroscopic full thickness rotator cuff repair: a real-world, propensity score-matched cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Preclinical Assessment of a Metformin-Melatonin Combination: Antinociceptive Synergism.Pharmaceutics · 2025Article
- Protective effects of pistachio hydroalcoholic extract on morphine-induced analgesic tolerance and dependence: investigating the impact of oxidative stress.Research in pharmaceutical sciences · 2024Article
- Seizing the Connection: Exploring the Interplay Between Epilepsy and Glycemic Control in Diabetes Management.Cureus · 2023Review
- Metformin in nucleus accumbens core reduces cue-induced cocaine seeking in male and female rats.Addiction biology · 2022Article
- Adenosine Monophosphate-activated Protein Kinase (AMPK) in serotonin neurons mediates select behaviors during protracted withdrawal from morphine in mice.Behavioural brain research · 2022Article
- Experimental Study on the Central Mechanism of Penehyclidine Hydrochloride against Relapse Behavior in Morphine-Dependent Rats.Applied bionics and biomechanics · 2022Article
- Effects of valsartan on morphine tolerance and dependence in rats.Research in pharmaceutical sciences · 2021Article
- The role of locus coeruleus nucleus TRPV1 receptors in the development and expression of morphine dependence.Iranian journal of basic medical sciences · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opiate tolerance and dependence is a worldwide public health problem and gives a significant burden to society. The aim of this study was to evaluate the effects of metformin (MET) on development and expression of morphine tolerance and dependence in rats. For induction of tolerance, morphine sulfate was injected (10 mg/kg, twice a day, s.c.) for 7 days. Animals received metformin (5 and 50 mg/kg, orally, daily) during the examination period for assessing the development of morphine tolerance and dependence. In order to evaluate the expression of morphine tolerance and dependence, single doses of MET (5 and 50 mg/kg, orally) were administered on day 7. Tail flick test was performed to assess the induction of morphine tolerance. For evaluation of morphine dependence, naloxone-induced jumping (5 mg/kg, s.c.) was monitored. Our results showed that 7 days coadministration of 50 mg/kg of MET significantly reduced the development of morphine analgesic tolerance versus morphine + saline treated rats (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.