Evidence map›Paper›PMID 30065706›Full record

ArticleFrontiers in microbiology2018

When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing.

Vladimir Lazarevic, Nadia Gaïa, Myriam Girard, Stefano Leo, Abdessalam Cherkaoui, Gesuele Renzi, Stéphane Emonet, Sharon Jamme, Etienne Ruppé, Sandrine Vijgen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Article
  4. Review
  5. Rapid identification by MALDI-TOF/MS and antimicrobial disk diffusion susceptibility testing for positive blood cultures after a short incubation on the WASPLab.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020
    Article
  6. Review
  7. Changes in Microbiota Profiles After Prolonged Frozen Storage of Stool Suspensions.Frontiers in cellular and infection microbiology · 2020
    Article
  8. Article
  9. Article
  10. Rare Case of Community-Acquired Endocarditis Caused byFrontiers in cardiovascular medicine · 2019
    Article
  11. Cyberbiosecurity Challenges of Pathogen Genome Databases.Frontiers in bioengineering and biotechnology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Vladimir LazarevicGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Nadia GaïaGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Myriam GirardGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Stefano LeoGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Abdessalam CherkaouiBacteriology Laboratory, Department of Genetics and Laboratory Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Gesuele RenziBacteriology Laboratory, Department of Genetics and Laboratory Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Stéphane EmonetBacteriology Laboratory, Department of Genetics and Laboratory Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Sharon JammeDepartment of Community, Primary Care and Emergency Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Etienne RuppéGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Sandrine VijgenDivision of Clinical Pathology, Department of Genetics and Laboratory Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Laura Rubbia-BrandtDivision of Clinical Pathology, Department of Genetics and Laboratory Medicine, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Christian TosoDepartment of Surgery, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
Jacques SchrenzelGenomic Research Laboratory, Division of Infectious Diseases, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
University Hospital of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Here, we sequenced DNA extracted from a necrotic hepatic lesion from a patient with suspected chronic hepatic brucelloma but negative culture results. Although most of the taxonomically classified sequencing reads corresponded to human genome sequences, our data suggest that whole-metagenome shotgun sequencing may be used together with other tests to strengthen the diagnosis of hepatic brucelloma.

Indexed as

Brucellaclinical metagenomicsliver abscessmolecular diagnosis of infectious diseasesnext-generation sequencing

Identifiers

PMID30065706
PMCPMC6056729
OpenAlexW2849515803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.