Evidence map›Paper›PMID 30065645›Full record

ArticleFrontiers in aging neuroscience2018

Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis.

Andrée-Anne Berthiaume, David A Hartmann, Mark W Majesky, Narayan R Bhat, Andy Y Shih

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  18. Article
  19. Article
  20. Role of autophagy in angiogenic potential of vascular pericytes.Frontiers in cell and developmental biology · 2024
    Review

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrée-Anne BerthiaumeDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
David A HartmannDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
Mark W MajeskyCenter for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle, WA, United States.
Narayan R BhatDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.
Andy Y ShihDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, United States.

Funding

Treating Depression and Enhancing Locomotor Recovery Post-strokeP20GM109040 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI KAUTZ, STEVEN A. · 2014 to 2024
$23.5M
Reprogramming of mature smooth muscle cells to vascular progenitor cellsR01HL121877 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MARK W. MAJESKY, Mary CM Weiser-Evans · 2015 to 2026
$7.8M
Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
Resident Progenitor Cells in the AdventitiaR01HL123650 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI MAJESKY, MARK W. · 2014 to 2017
$2.4M
Pericytes as Inducers of Blood-brain Barrier Injury During StrokeR21NS096997 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BHAT, NARAYAN R, SHIH, ANDY Y · 2016 to 2017
$411k
Targeting Neurovascular Dysfunction in ADR21AG052321 · NIA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BHAT, NARAYAN R · 2016 to 2017
$411k
Enhanced Detection of Cerebral Microinfarcts in Dementia Using MRIR21NS085402 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SHIH, ANDY Y · 2013 to 2014
$409k
A Potential New Role for Pericytes in Functional HyperemiaF30NS096868 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HARTMANN, DAVID ANTHONY · 2016 to 2019
$177k
NHLBI NIH HHS R01 HL121877NHLBI NIH HHS R01 HL123650NHLBI NIH HHS R01 HL133723NIA NIH HHS R21 AG052321NIGMS NIH HHS P20 GM109040NINDS NIH HHS F30 NS096868NINDS NIH HHS R21 NS085402NINDS NIH HHS R21 NS096997
6 · The paper itself

Abstract

The biology of brain microvascular pericytes is an active area of research and discovery, as their interaction with the endothelium is critical for multiple aspects of cerebrovascular function. There is growing evidence that pericyte loss or dysfunction is involved in the pathogenesis of Alzheimer's disease, vascular dementia, ischemic stroke and brain injury. However, strategies to mitigate or compensate for this loss remain limited. In this review, we highlight a novel finding that pericytes in the adult brain are structurally dynamic

Indexed as

Alzheimer’s diseaseblood-brain barriercapillary blood flowmural cellneurovascular couplingpericytestroketwo-photon imaging

Identifiers

PMID30065645
PMCPMC6057109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.