Evidence map›Paper›PMID 30065623›Full record

ReviewFrontiers in neuroscience2018

Nano-Architectural Approaches for Improved Intracortical Interface Technologies.

Youjoung Kim, Seth M Meade, Keying Chen, He Feng, Jacob Rayyan, Allison Hess-Dunning, Evon S Ereifej

Abstract readReview
In one paragraph

Review in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. RepositioningPharmaceutics · 2020
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Youjoung KimDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Seth M MeadeDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Keying ChenDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
He FengDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Jacob RayyanDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Allison Hess-DunningDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.
Evon S EreifejDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States.

Funding

Therapeutic and Topographical Approaches for Improved Neural Electrode BiocompatibilityIK1RX001664 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI EREIFEJ, EVON S. · 2015 to 2016
–
Flexible Multi-Sensory Mode Neural Devices for Neurochemical ControlIK2RX001841 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DUNNING, ALLISON HESS · 2015 to 2018
–
Mimicking the Architecture and Modulus of Native Brain Tissue onto Neural Implants to Improve BiocompatibilityIK2RX002628 · VA · VETERANS HEALTH ADMINISTRATION · PI EREIFEJ, EVON S. · 2018 to 2021
–
RRD VA IK1 RX001664RRD VA IK2 RX001841RRD VA IK2 RX002628
6 · The paper itself

Abstract

Intracortical microelectrodes (IME) are neural devices that initially were designed to function as neuroscience tools to enable researchers to understand the nervous system. Over the years, technology that aids interfacing with the nervous system has allowed the ability to treat patients with a wide range of neurological injuries and diseases. Despite the substantial success that has been demonstrated using IME in neural interface applications, these implants eventually fail due to loss of quality recording signals. Recent strategies to improve interfacing with the nervous system have been inspired by methods that mimic the native tissue. This review focusses on one strategy in particular, nano-architecture, a term we introduce that encompasses the approach of roughening the surface of the implant. Various nano-architecture approaches have been hypothesized to improve the biocompatibility of IMEs, enhance the recording quality, and increase the longevity of the implant. This review will begin by introducing IME technology and discuss the challenges facing the clinical deployment of IME technology. The biological inspiration of nano-architecture approaches will be explained as well as leading fabrication methods used to create nano-architecture and their limitations. A review of the effects of nano-architecture surfaces on neural cells will be examined, depicting the various cellular responses to these modified surfaces in both

Indexed as

intracortical microelectrodesmechanotransductionnano-architectureneuroinflammationtopography

Identifiers

PMID30065623
PMCPMC6056633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.