ReviewWorld journal of gastroenterology2018
Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients.
Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group.Journal of pediatric gastroenterology and nutrition · 2025Guideline
- Safety of Biologic Therapy for Inflammatory Bowel Disease in Liver Transplant Recipients.Biomedicines · 2026Article
- Distinct phenotype of primary sclerosing cholangitis-associated inflammatory bowel disease.Journal of gastroenterology · 2026Review
- Current Treatment of Primary Biliary Cholangitis and Primary Sclerosing Cholangitis: A Comprehensive Review.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Review
- Long-term Outcomes Following Colectomy and Liver Transplantation for Inflammatory Bowel Disease With Primary Sclerosing Cholangitis.Annals of surgery · 2026Article
- Postoperative detection ofTransplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Recurrent sclerosing cholangitis post-transplant: increased recurrence rates following re-transplantation.Irish journal of medical science · 2024Article
- [Liver transplantation in viral and autoimmune liver diseases].Innere Medizin (Heidelberg, Germany) · 2024Review
- Impact of liver transplantation on intestinal and systemic inflammation markers in patients with colitis ulcerosa concomitant with primary sclerosing cholangitis.Przeglad gastroenterologiczny · 2024Article
- Colectomy in patients with ulcerative colitis is not associated to future diagnosis of primary sclerosing cholangitis.United European gastroenterology journal · 2023Article
- Inflammatory conditions play a role in recurrence of PSC after liver transplantation: An international multicentre study.JHEP reports : innovation in hepatology · 2022Article
- Posttransplant considerations in autoimmune liver disease: Recurrence of disease andClinical liver disease · 2022Review
- Systematic review and meta-analysis: the impact of co-occurring immune-mediated inflammatory diseases on the disease localization and behavior of Crohn's disease.Therapeutic advances in gastroenterology · 2021Article
- Recurrence of primary sclerosing cholangitis after liver transplantation is associated with specific changes in the gut microbiome pretransplant - a pilot study.Transplant international : official journal of the European Society for Organ Transplantation · 2020Article
- Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation.World journal of gastroenterology · 2020Article
- Targeting the Gut Microbiome as a Treatment for Primary Sclerosing Cholangitis: A Conceptional Framework.The American journal of gastroenterology · 2020Review
- Essential updates 2018/2019: Liver transplantation.Annals of gastroenterological surgery · 2020Review
- Specific Features of Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis.Journal of clinical medicine research · 2019Review
- Treatment of primary sclerosing cholangitis in children.World journal of hepatology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the published evidence on the impact of colectomy in preventing recurrent primary sclerosing cholangitis (rPSC).
methodsAn unrestricted systematic literature search in PubMed, EMBASE, Medline OvidSP, ISI Web of Science, Lista (EBSCO) and the Cochrane library was performed on clinical studies investigating colectomy in liver transplantation (LT) recipients with and without rPSC in the liver allograft. Study quality was evaluated according to a modification of the methodological index for non-randomized studies (MINORS) criteria. Primary endpoints were the impact of presence, timing and type of colectomy on rPSC. Overall presence of inflammatory bowel disease (IBD), time of IBD diagnosis, posttransplant IBD and immunosuppressive regimen were investigated as secondary outcome.
resultsThe literature search yielded a total of 180 publications. No randomized controlled trial was identified. Six retrospective studies met the inclusion criteria of which 5 studies were graded as high quality articles. Reporting of IBD was heterogenous but in four publications, either inflammatory bowel disease, ulcerative colitis or in particular active colitis post-LT significantly increased the risk of rPSC. The presence of an intact (
conclusionThe data favours a protective role of pre-/peri-LT colectomy in rPSC but the current evidence is not strong enough to recommend routine colectomy for rPSC prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.