Evidence map›Paper›PMID 30065559›Full record

ArticleWorld journal of gastroenterology2018

Moxibustion treatment modulates the gut microbiota and immune function in a dextran sulphate sodium-induced colitis rat model.

Qin Qi, Ya-Nan Liu, Xiao-Ming Jin, Lin-Shuang Zhang, Cun Wang, Chun-Hui Bao, Hui-Rong Liu, Huan-Gan Wu, Xiao-Mei Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
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  5. Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025
    Article
  6. Keratin 1 modulates intestinal barrier and immune responseWorld journal of gastroenterology · 2025
    Article
  7. Review
  8. Acupuncture influences multiple diseases by regulating gut microbiota.Frontiers in cellular and infection microbiology · 2024
    Review
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Qin QiYueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Ya-Nan LiuYueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Xiao-Ming JinStark Neurosciences Research Institute and Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, United States.
Lin-Shuang ZhangZhejiang Institute for Food and Drug Control, Hangzhou 310052, Zhejiang Province, China.
Cun WangYueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Chun-Hui BaoShanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
Hui-Rong LiuShanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
Huan-Gan WuShanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
Xiao-Mei WangShanghai Research Institute of Acupuncture-moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine, Shanghai 200030, China.
ZheJiang Institute For Food and Drug Control · CNYueyang Hospital · CNNeurosciences Institute · USShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effect and mechanism of moxibustion in rats with ulcerative colitis.

methodsA rat colitis model was established by administering 4% dextran sulphate sodium solution. Seventy male rats were randomly divided into seven groups: Healthy controls (HC), ulcerative colitis model group (UC), UC with 7 d of moxibustion (UC-7), UC with 14 d of moxibustion (UC-14), UC with mesalazine gavage (UC-W), HC with 7 d of moxibustion (HC-7), HC with 14 d of moxibustion (HC-14). Moxibustion was applied to the bilateral Tianshu (ST25). Gut microbiome profiling was conducted by 16S rRNA amplicon sequencing, and PCR and ELISA determined the expression of inflammatory cytokines in colon mucosa and serum, respectively.

resultsMoxibustion treatment restored the colonic mucosa and decreased submucosal inflammatory cell infiltration in colitis rats. Rats treated with moxibustion and mesalazine had significantly lower levels of the dominant phyla Proteobacteria and the genera

conclusionOur findings suggest that moxibustion exerts its therapeutic effect by repairing mucosal tissue damage and modulating the gut microbiome and intestinal mucosal immunity.

Indexed as

MoxibustionAnimalsBacteriaColitis, UlcerativeColonCytokinesDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeHumansIntestinal MucosaMaleProteobacteriaRatsRats, Sprague-DawleyRNA, Ribosomal, 16SCytokinesDextran SulfateRNA, Ribosomal, 16S16S rRNAGut microbiomeInflammatory cytokineMoxibustionUlcerative colitis

Identifiers

PMID30065559
PMCPMC6064969
OpenAlexW2883544426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.